PMID- 23177044
OWN - NLM
STAT- MEDLINE
DCOM- 20130607
LR  - 20211203
IS  - 1873-2682 (Electronic)
IS  - 1011-1344 (Print)
IS  - 1011-1344 (Linking)
VI  - 118
DP  - 2013 Jan 5
TI  - Contrasting binding of fisetin and daidzein in gamma-cyclodextrin nanocavity.
PG  - 33-41
LID - S1011-1344(12)00228-X [pii]
LID - 10.1016/j.jphotobiol.2012.10.010 [doi]
AB  - Steady state and time resolved fluorescence along with anisotropy and induced 
      circular dichroism (ICD) spectroscopy provide useful tools to observe and 
      understand the behavior of the therapeutically important plant flavonoids fisetin 
      and daidzein in gamma-cyclodextrin (gamma-CDx) nanocavity. Benesi-Hildebrand plots 
      indicated 1:1 stoichiometry for both the supramolecular complexes. However, the 
      mode of the binding of fisetin significantly differs from daidzein in gamma-CDx, as 
      is observed from ICD spectra which is further confirmed by docking studies. The 
      interaction with gamma-CDx proceeds mainly by the phenyl ring and partly by the 
      chromone ring of fisetin whereas only the phenyl ring takes part for daidzein. A 
      linear increase in the aqueous solubility of the flavonoids is assessed from the 
      increase in the binding of the flavonoids with the gamma-CDx cavity, which are 
      determined by the gradual increase in the ICD signal, fluorescence emission as 
      well as increase in fluorescence anisotropy with increasing (gamma-CDx). This 
      confirms gamma-CDx as a nanovehicle for the flavonoids fisetin and daidzein in 
      improving their bioavailability.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Pahari, Biswapathik
AU  - Pahari B
AD  - Biophysics Division, Saha Institute of Nuclear Physics, Kolkata 700 064, India.
FAU - Sengupta, Bidisha
AU  - Sengupta B
FAU - Chakraborty, Sandipan
AU  - Chakraborty S
FAU - Thomas, Briannica
AU  - Thomas B
FAU - McGowan, Dyffreyon
AU  - McGowan D
FAU - Sengupta, Pradeep K
AU  - Sengupta PK
LA  - eng
GR  - P20 MD002725/MD/NIMHD NIH HHS/United States
GR  - 1P20MD002725/MD/NIMHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20121101
PL  - Switzerland
TA  - J Photochem Photobiol B
JT  - Journal of photochemistry and photobiology. B, Biology
JID - 8804966
RN  - 0 (Flavonoids)
RN  - 0 (Flavonols)
RN  - 0 (Isoflavones)
RN  - 0 (gamma-Cyclodextrins)
RN  - 6287WC5J2L (daidzein)
RN  - KZJ0BYZ5VA (gamma-cyclodextrin)
RN  - OO2ABO9578 (fisetin)
SB  - IM
MH  - Circular Dichroism
MH  - Flavonoids/*chemistry
MH  - Flavonols
MH  - Fluorescence Polarization
MH  - Isoflavones/*chemistry
MH  - Molecular Docking Simulation
MH  - Spectrometry, Fluorescence
MH  - gamma-Cyclodextrins/*chemistry
PMC - PMC3553589
MID - NIHMS419005
EDAT- 2012/11/28 06:00
MHDA- 2013/06/08 06:00
PMCR- 2014/01/05
CRDT- 2012/11/27 06:00
PHST- 2012/09/13 00:00 [received]
PHST- 2012/10/21 00:00 [revised]
PHST- 2012/10/22 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/06/08 06:00 [medline]
PHST- 2014/01/05 00:00 [pmc-release]
AID - S1011-1344(12)00228-X [pii]
AID - 10.1016/j.jphotobiol.2012.10.010 [doi]
PST - ppublish
SO  - J Photochem Photobiol B. 2013 Jan 5;118:33-41. doi: 
      10.1016/j.jphotobiol.2012.10.010. Epub 2012 Nov 1.