PMID- 23177245
OWN - NLM
STAT- MEDLINE
DCOM- 20130701
LR  - 20131121
IS  - 1873-3336 (Electronic)
IS  - 0304-3894 (Linking)
VI  - 244-245
DP  - 2013 Jan 15
TI  - The associations between serum perfluorinated chemicals and thyroid function in 
      adolescents and young adults.
PG  - 637-44
LID - S0304-3894(12)01066-7 [pii]
LID - 10.1016/j.jhazmat.2012.10.049 [doi]
AB  - Perfluorinated chemicals (PFCs) have been widely used in a variety of products 
      worldwide for years. However, the effect of PFCs on thyroid function has not yet 
      been clearly defined. We recruited 567 subjects (aged 12-30 years) in a 
      population-based cohort of adolescents and young adults with abnormal urinalysis 
      in the childhood to determine the relationship between serum level of PFCs and 
      the levels of serum free thyroxine (T4) and thyroid stimulating hormone (TSH). 
      The geometric means and geometric standard deviation concentrations of 
      perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), 
      perfluorononanoic acid (PFNA) and perfluoroundecanoic acid (PFUA) were 2.67 
      (2.96) ng/ml, 7.78 (2.42) ng/ml, 1.01 (3.48) ng/ml and 5.81 (2.92) ng/ml, 
      respectively. Differences in the levels of free T4 and TSH across different 
      categories of PFOA, PFOS and PFUA were insignificant. After controlling for 
      confounding factors, multiple linear regression analyses revealed mean serum 
      level of free T4 increased significantly across categories (<60th, 60-89 and 
      >90th percentiles) of PFNA (P for trend =0.012 in the full model). The 
      association between PFNA and free T4 was more significant in male subjects in age 
      group 20-30, active smokers and in those with higher body mass index in 
      stratified analysis. Serum concentrations of PFNA were associated with serum free 
      T4 levels in adolescents and young adults.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Lin, Chien-Yu
AU  - Lin CY
AD  - Department of Internal Medicine, En Chu Kong Hospital, New Taipei City 237, 
      Taiwan.
FAU - Wen, Li-Li
AU  - Wen LL
FAU - Lin, Lian-Yu
AU  - Lin LY
FAU - Wen, Ting-Wen
AU  - Wen TW
FAU - Lien, Guang-Wen
AU  - Lien GW
FAU - Hsu, Sandy H J
AU  - Hsu SH
FAU - Chien, Kuo-Liong
AU  - Chien KL
FAU - Liao, Chien-Chang
AU  - Liao CC
FAU - Sung, Fung-Chang
AU  - Sung FC
FAU - Chen, Pau-Chung
AU  - Chen PC
FAU - Su, Ta-Chen
AU  - Su TC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121102
PL  - Netherlands
TA  - J Hazard Mater
JT  - Journal of hazardous materials
JID - 9422688
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
RN  - 9002-71-5 (Thyrotropin)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alkanesulfonic Acids/*blood
MH  - Child
MH  - Cohort Studies
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Fluorocarbons/*blood
MH  - Humans
MH  - Male
MH  - Taiwan/epidemiology
MH  - Thyroid Gland/physiology
MH  - Thyrotropin/*blood
MH  - Thyroxine/*blood
MH  - Young Adult
EDAT- 2012/11/28 06:00
MHDA- 2013/07/03 06:00
CRDT- 2012/11/27 06:00
PHST- 2012/08/14 00:00 [received]
PHST- 2012/10/25 00:00 [revised]
PHST- 2012/10/26 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
AID - S0304-3894(12)01066-7 [pii]
AID - 10.1016/j.jhazmat.2012.10.049 [doi]
PST - ppublish
SO  - J Hazard Mater. 2013 Jan 15;244-245:637-44. doi: 10.1016/j.jhazmat.2012.10.049. 
      Epub 2012 Nov 2.