PMID- 23178910
OWN - NLM
STAT- MEDLINE
DCOM- 20130701
LR  - 20131121
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 230
DP  - 2013 Jan 29
TI  - The effects of voluntary running exercise coincidence with social isolation after 
      early weaning on monoaminergic axonal development.
PG  - 31-8
LID - S0306-4522(12)01131-1 [pii]
LID - 10.1016/j.neuroscience.2012.11.020 [doi]
AB  - The axonal development of serotonin (5-HT)-, noradrenaline (NA)-, or tyrosine 
      hydroxylase (TH)-containing monoaminergic neurons is affected by rearing 
      conditions during the juvenile period. Impaired monoaminergic axonal development 
      is implicated in the pathophysiology of emotional and cognitive dysfunction. On 
      the other hand, exercise may have beneficial effects on emotional and learning 
      performance in adults. We have examined whether voluntary running exercise during 
      social isolation after early weaning (early weaning/social isolation; EI) from 
      postnatal day (PD) 14-28 could prevent the impaired monoaminergic axonal 
      development associated with EI. Compared with control animals reared with their 
      dam and siblings until PD28, the EI animals showed lower density of 5-HT and NA 
      axons in the dorsal-medial prefrontal cortex (mPFC) and basolateral nucleus of 
      the amygdala and of NA- and TH-containing axons in the ventral-mPFC. These 
      adverse effects of EI were not observed in rats taking part in voluntary running 
      (EI+R) when these animals were compared to controls. The 5-HT axon density in the 
      ventral-mPFC was significantly higher in the EI+R rats than that in the EI rats, 
      although both these values were significantly lower than those in the control 
      rats. The density of monoaminergic axons in the dentate gyrus and CA3 of the 
      hippocampus was not affected by either EI or EI+R. These results suggest that the 
      beneficial effects of voluntary running may be because of the modulation of 
      monoaminergic axonal morphology. Our findings will hopefully provide the basis 
      for future research into the beneficial effects of voluntary exercise during the 
      juvenile period on brain development and emotional and cognitive performance.
CI  - Copyright (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Ishikawa, J
AU  - Ishikawa J
AD  - Systems Neuroscience, Department of Neuroscience, Yamaguchi University Graduate 
      School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan. 
      junko-lc@yamaguchi-u.ac.jp
FAU - Ishikawa, A
AU  - Ishikawa A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121120
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Biogenic Monoamines)
RN  - 333DO1RDJY (Serotonin)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
RN  - EC 1.14.17.1 (Dopamine beta-Hydroxylase)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - Axons/*metabolism
MH  - Biogenic Monoamines/*metabolism
MH  - *Brain/cytology/growth & development/metabolism
MH  - Dopamine beta-Hydroxylase/metabolism
MH  - Gene Expression Regulation, Developmental/physiology
MH  - Locomotion/*physiology
MH  - Male
MH  - Norepinephrine/metabolism
MH  - *Physical Conditioning, Animal
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/metabolism
MH  - Social Isolation/*psychology
MH  - Tyrosine 3-Monooxygenase/metabolism
MH  - Weaning
EDAT- 2012/11/28 06:00
MHDA- 2013/07/03 06:00
CRDT- 2012/11/27 06:00
PHST- 2012/08/22 00:00 [received]
PHST- 2012/11/07 00:00 [revised]
PHST- 2012/11/08 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
AID - S0306-4522(12)01131-1 [pii]
AID - 10.1016/j.neuroscience.2012.11.020 [doi]
PST - ppublish
SO  - Neuroscience. 2013 Jan 29;230:31-8. doi: 10.1016/j.neuroscience.2012.11.020. Epub 
      2012 Nov 20.