PMID- 23179355
OWN - NLM
STAT- MEDLINE
DCOM- 20130816
LR  - 20240408
IS  - 1557-1904 (Electronic)
IS  - 1557-1890 (Print)
IS  - 1557-1890 (Linking)
VI  - 8
IP  - 1
DP  - 2013 Mar
TI  - MDMA increases glutamate release and reduces parvalbumin-positive GABAergic cells 
      in the dorsal hippocampus of the rat: role of cyclooxygenase.
PG  - 58-65
LID - 10.1007/s11481-012-9420-x [doi]
AB  - 3,4-Methylenedioxymethamphetamine (MDMA; Ecstasy) is a popular drug of abuse with 
      well-documented acute effects on serotonergic, dopaminergic, and cholinergic 
      transmitter systems, as well as evidence of long-term disruption of 
      serotoninergic systems in the rat brain. Recently, it was demonstrated that MDMA 
      evokes a delayed and sustained increase in glutamate release in the hippocampus. 
      The purpose of the present study was to determine the role of inflammatory 
      mediators in the MDMA-induced increase in glutamate release, as well as the 
      contribution of inflammatory pathways in the persistent neurochemical toxicity 
      associated with repeated MDMA treatment. Treatment with the non-selective 
      cyclooxygenase (COX) inhibitor ketoprofen and the COX-2 selective inhibitor 
      nimesulide attenuated the increase in extracellular glutamate in the hippocampus 
      evoked by repeated MDMA exposure (10 mg/kg, i.p., every 2 h); no attenuation was 
      observed in rats treated with the COX-1 selective inhibitor piroxicam. Reverse 
      dialysis of a major product of COX activity, prostaglandin E2, also resulted in a 
      significant increase in extracellular glutamate in the hippocampus . Repeated 
      exposure to MDMA diminished the number of parvalbumin-positive GABA interneurons 
      in the dentate gyrus of the hippocampus, an effect that was attenuated by 
      ketoprofen treatment. However, COX inhibition with ketoprofen did not prevent the 
      long-term depletion of 5-HT in the hippocampus evoked by MDMA treatment. These 
      data are supportive of the view that cyclooxygenase activity contributes to the 
      mechanism underlying both the increased release of glutamate and decreased number 
      of GABA interneurons in the rat hippocampus produced by repeated MDMA exposure.
FAU - Anneken, John H
AU  - Anneken JH
AD  - James Winkle College of Pharmacy, University of Cincinnati, 3225 Eden Ave, 
      Cincinnati, OH 45267, USA.
FAU - Cunningham, Jacobi I
AU  - Cunningham JI
FAU - Collins, Stuart A
AU  - Collins SA
FAU - Yamamoto, Bryan K
AU  - Yamamoto BK
FAU - Gudelsky, Gary A
AU  - Gudelsky GA
LA  - eng
GR  - DA 07427/DA/NIDA NIH HHS/United States
GR  - R01 DA007606/DA/NIDA NIH HHS/United States
GR  - DA016886/DA/NIDA NIH HHS/United States
GR  - R01 DA016866/DA/NIDA NIH HHS/United States
GR  - R01 DA007427/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20121118
PL  - United States
TA  - J Neuroimmune Pharmacol
JT  - Journal of neuroimmune pharmacology : the official journal of the Society on 
      NeuroImmune Pharmacology
JID - 101256586
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - 0 (Cyclooxygenase Inhibitors)
RN  - 0 (Parvalbumins)
RN  - 333DO1RDJY (Serotonin)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 90Y4QC304K (Ketoprofen)
RN  - EC 1.14.99.1 (Prostaglandin-Endoperoxide Synthases)
RN  - K7Q1JQR04M (Dinoprostone)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adrenergic Uptake Inhibitors/*pharmacology
MH  - Animals
MH  - Cell Count
MH  - Chromatography, High Pressure Liquid
MH  - Cyclooxygenase Inhibitors/pharmacology
MH  - Dentate Gyrus/cytology/drug effects
MH  - Dinoprostone/metabolism
MH  - Glutamic Acid/*metabolism
MH  - Hippocampus/*cytology/drug effects/enzymology
MH  - Immunohistochemistry
MH  - Interneurons/drug effects
MH  - Ketoprofen/pharmacology
MH  - Male
MH  - Microdialysis
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Parvalbumins/*metabolism
MH  - Presynaptic Terminals/drug effects
MH  - Prostaglandin-Endoperoxide Synthases/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/metabolism
MH  - gamma-Aminobutyric Acid/*physiology
PMC - PMC3587367
MID - NIHMS424160
EDAT- 2012/11/28 06:00
MHDA- 2013/08/21 06:00
PMCR- 2014/03/01
CRDT- 2012/11/27 06:00
PHST- 2012/08/29 00:00 [received]
PHST- 2012/11/05 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
PHST- 2014/03/01 00:00 [pmc-release]
AID - 10.1007/s11481-012-9420-x [doi]
PST - ppublish
SO  - J Neuroimmune Pharmacol. 2013 Mar;8(1):58-65. doi: 10.1007/s11481-012-9420-x. 
      Epub 2012 Nov 18.