PMID- 23179937
OWN - NLM
STAT- MEDLINE
DCOM- 20130809
LR  - 20211021
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Print)
IS  - 0937-4477 (Linking)
VI  - 270
IP  - 3
DP  - 2013 Mar
TI  - High expression levels of COX-2 and P300 are associated with unfavorable survival 
      in laryngeal squamous cell carcinoma.
PG  - 1009-17
LID - 10.1007/s00405-012-2275-1 [doi]
AB  - In order to provide a basis for clinical treatment decisions, we explored whether 
      there was a correlation between the expression of COX-2 and P300 and clinical 
      factors in a group of patients with laryngeal squamous cell carcinoma (LSCC). A 
      retrospective analysis of clinicopathological data was conducted in 80 patients 
      with LSCC who presented between January 1997 and December 1998. An 
      immunohistochemistry tissue microarray was conducted of 80 surgically resected 
      LSCC and 20 adjacent normal tissue specimens. Survival analysis and Kaplan-Meier 
      curves were used to compare the effects of clinicopathological factors on 
      survival. The Cox model was applied for multivariate analysis. The expression 
      level of COX-2/P300 in LSCC tissues and adjacent normal tissues were 47.5/50.0 
      versus 0.0/15.0 %. The expression of COX-2 and P300 was correlated with higher T 
      category, N category, clinical staging, histological grade and recurrence (P < 
      0.05). P300 expression was correlated with COX-2 expression (P < 0.05). 
      Univariate survival analysis showed that P300, COX-2, N category, clinical 
      staging and recurrence factors were closely correlated with unfavorable survival 
      (P < 0.05). Multivariate analysis showed that COX-2 expression, histological 
      grade and recurrence were independent prognostic factors for LSCC. High 
      expression levels of COX-2 and P300 indicated poor survival outcomes for patients 
      with LSCC.
FAU - Chen, Yan-Feng
AU  - Chen YF
AD  - State Key Laboratory of Oncology in South China, Department of Head and Neck 
      Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People's 
      Republic of China. chenyf@sysucc.org.cn
FAU - Luo, Rong-Zhen
AU  - Luo RZ
FAU - Li, Yong
AU  - Li Y
FAU - Cui, Bo-Kang
AU  - Cui BK
FAU - Song, Ming
AU  - Song M
FAU - Yang, An-Kui
AU  - Yang AK
FAU - Chen, Wen-Kuan
AU  - Chen WK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121124
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - EC 1.14.99.1 (PTGS2 protein, human)
RN  - EC 2.3.1.48 (E1A-Associated p300 Protein)
RN  - EC 2.3.1.48 (EP300 protein, human)
SB  - IM
MH  - Carcinoma, Squamous Cell/*metabolism/mortality
MH  - Cyclooxygenase 2/*metabolism
MH  - E1A-Associated p300 Protein/*metabolism
MH  - Female
MH  - Head and Neck Neoplasms/*metabolism/mortality
MH  - Humans
MH  - Immunohistochemistry
MH  - Kaplan-Meier Estimate
MH  - Laryngeal Neoplasms/*metabolism/mortality
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Tissue Array Analysis
PMC - PMC3580132
COIS- The authors declare that they have no conflict of interest.
EDAT- 2012/11/28 06:00
MHDA- 2013/08/10 06:00
PMCR- 2012/11/24
CRDT- 2012/11/27 06:00
PHST- 2012/08/26 00:00 [received]
PHST- 2012/11/07 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/08/10 06:00 [medline]
PHST- 2012/11/24 00:00 [pmc-release]
AID - 2275 [pii]
AID - 10.1007/s00405-012-2275-1 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2013 Mar;270(3):1009-17. doi: 
      10.1007/s00405-012-2275-1. Epub 2012 Nov 24.