PMID- 23180519
OWN - NLM
STAT- MEDLINE
DCOM- 20130708
LR  - 20201218
IS  - 1897-4279 (Electronic)
IS  - 0022-9032 (Linking)
VI  - 70
IP  - 11
DP  - 2012
TI  - Factors affecting long-term survival after aortic valve replacement.
PG  - 1120-9
AB  - BACKGROUND AND AIM: To evaluate long-term outcomes of surgical aortic valve 
      replacement (AVR) due to significant aortic stenosis (AS) and assess changes in 
      factors affecting survival during a 10-year period in patients referred for 
      surgery from a single centre. METHODS: We evaluated 1143 patients (478 women, 665 
      men; mean age 61 +/- 5 years) treated in the Department of Valvular Heart Disease 
      at the Institute of Cardiology in Warsaw who were referred for AVR due to 
      significant AS in 1998-2008 and survived the surgery and the initial 30-day 
      postoperative period. We assessed long-term survival in relation to preoperative 
      parameters including demographic data (age, gender), clinical variables (New York 
      Heart Association [NYHA] class, presence of a significant coronary artery 
      stenosis, arterial hypertension, reduced left ventricular ejection fraction 
      [LVEF]), and operative parameters (prosthetic valve type: biological vs. 
      mechanical, and the type of the surgery: isolated AVR vs. AVR combined with 
      coronary artery bypass grafting). RESULTS: Ten-year survival was worse in men 
      compared to women (p = 0.001), with the effect of gender gradually decreasing 
      after 3 years of follow-up. Factors affecting long-term survival included age (p 
      = 0.0001) and NYHA class (p = 0.005) in women, and age (p = 0.0001), NYHA class 
      (p = 0.0001), arterial hypertension (p = 0.01), reduced LVEF (p = 0.03), and the 
      presence of significant coronary artery stenoses (p = 0.0001) in men. Evaluation 
      of factors affecting 1-, 3-, 5-, and 7-year survival showed their variability 
      mostly in men. CONCLUSIONS: Long-term surgical outcomes in patients with 
      significant AS are very good, with better survival in women compared to men, 
      although these differences attenuated after 3 years. Factors affecting 10-year 
      survival are different in women and men: a significant effect in women was noted 
      only for age and preoperative NYHA class, while in men for age, NYHA class, 
      hypertension, reduced LVEF, and the presence of significant coronary artery 
      stenoses. During 10-year follow-up, longitudinal changes can be noted in factors 
      affecting survival after AVR.
FAU - Orlowska Baranowska, Ewa
AU  - Orlowska Baranowska E
AD  - Department of Valvular Heart Disease, Institute of Cardiology, Warsaw, Poland. 
      eorlowska@ikard.pl
FAU - Abramczuk, Elzbieta
AU  - Abramczuk E
FAU - Grabowski, Maciej
AU  - Grabowski M
FAU - Zakrzewski, Dariusz
AU  - Zakrzewski D
FAU - Milkowska, Malgorzata
AU  - Milkowska M
FAU - Galas, Anna
AU  - Galas A
FAU - Czerwinska, Katarzyna
AU  - Czerwinska K
FAU - Hryniewiecki, Tomasz
AU  - Hryniewiecki T
FAU - Baranowski, Rafal
AU  - Baranowski R
FAU - Piskorski, Jaroslaw
AU  - Piskorski J
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Kardiol Pol
JT  - Kardiologia polska
JID - 0376352
SB  - IM
MH  - Age Distribution
MH  - Age Factors
MH  - Aged
MH  - Aortic Valve/*surgery
MH  - Bicuspid Aortic Valve Disease
MH  - Comorbidity
MH  - Coronary Disease/epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Defects, Congenital/*mortality/*therapy
MH  - Heart Valve Diseases/*mortality/*therapy
MH  - Heart Valve Prosthesis
MH  - Heart Valve Prosthesis Implantation/*mortality
MH  - Humans
MH  - Hypertension/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Poland/epidemiology
MH  - Risk Factors
MH  - Sex Distribution
MH  - Sex Factors
MH  - Stroke Volume
MH  - Survival Rate
MH  - Treatment Outcome
EDAT- 2012/11/28 06:00
MHDA- 2013/07/09 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/07/09 06:00 [medline]
PST - ppublish
SO  - Kardiol Pol. 2012;70(11):1120-9.