PMID- 23180587
OWN - NLM
STAT- MEDLINE
DCOM- 20140325
LR  - 20221207
IS  - 1399-3003 (Electronic)
IS  - 0903-1936 (Linking)
VI  - 42
IP  - 3
DP  - 2013 Sep
TI  - Determinants of, and reference equation for, exhaled nitric oxide in the Chinese 
      population.
PG  - 767-75
LID - 10.1183/09031936.00130112 [doi]
AB  - Measurement of fractional exhaled nitric oxide concentration (FeNO) has been 
      proposed as a useful biomarker for monitoring and management of airway diseases. 
      Limited information is available regarding reference levels of FeNO levels in 
      Chinese adults. This study aimed to investigate the reference equation and 
      determinants of FeNO in Chinese adults. 1093 (577 males) healthy nonsmoking 
      subjects aged 18-90 years were recruited. FeNO was measured online using a 
      chemiluminescence analyser. Other assessments included spirometry, skin prick 
      tests, total serum IgE levels and eosinophil count in peripheral blood. The 
      geometric mean FeNO was 32.6 (95% reference interval (RI) 31.4-33.7) ppb for all 
      subjects. FeNO values were higher in males than females (geometric mean (95% RI) 
      38.3 (36.5-40.2) ppb versus 27.1 (25.8-28.5) ppb, p<0.0001), and in atopic than 
      nonatopic subjects (34.6 (33.0-36.3) ppb versus 29.8 (28.3-31.4) ppb, p<0.0001). 
      FeNO correlated with age (r(2) = 0.23), height (r(2) = 0.20), IgE level (r(2) = 
      0.18) and percentage eosinophil count (r(2) = 0.18) (all p<0.0001), but not with 
      spirometric parameters. Based on multiple regression modelling, the reference 
      equation of FeNO value was: log(FeNO) = 0.781 + 0.104(sex) + 0.004(age) + 
      0.084(atopy) + 0.003(height in cm), where for sex 1 = male and 0 = female, age is 
      measured in years, for atopy 1 = atopic and 0 = nonatopic, and height is measured 
      in cm. The FeNO of Chinese adults is higher than that of the Caucasian 
      population, and is affected by age, sex, height and atopic status. This study 
      provides useful references for the interpretation of FeNO.
FAU - Ko, Fanny W S
AU  - Ko FW
AD  - Dept of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong 
      Kong, China. fannyko@cuhk.edu.hk
FAU - Leung, Ting F
AU  - Leung TF
FAU - Wong, Gary W K
AU  - Wong GW
FAU - Chu, Jojo H Y
AU  - Chu JH
FAU - Sy, Hing Y
AU  - Sy HY
FAU - Hui, David S C
AU  - Hui DS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121122
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (Biomarkers)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - *Asian People
MH  - Biomarkers/metabolism
MH  - Body Height
MH  - Breath Tests
MH  - Eosinophils
MH  - Female
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Hypersensitivity, Immediate/ethnology
MH  - Immunoglobulin E/blood
MH  - Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/*metabolism
MH  - Reference Values
MH  - Sex Factors
MH  - Skin Tests
MH  - Spirometry
MH  - Young Adult
EDAT- 2012/11/28 06:00
MHDA- 2014/03/26 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2014/03/26 06:00 [medline]
AID - 09031936.00130112 [pii]
AID - 10.1183/09031936.00130112 [doi]
PST - ppublish
SO  - Eur Respir J. 2013 Sep;42(3):767-75. doi: 10.1183/09031936.00130112. Epub 2012 
      Nov 22.