PMID- 23181351
OWN - NLM
STAT- MEDLINE
DCOM- 20130426
LR  - 20211021
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Print)
IS  - 0019-2805 (Linking)
VI  - 138
IP  - 4
DP  - 2013 Apr
TI  - All-trans-retinoic acid ameliorates experimental allergic encephalomyelitis by 
      affecting dendritic cell and monocyte development.
PG  - 333-45
LID - 10.1111/imm.12040 [doi]
AB  - Experimental allergic encephalomyelitis (EAE) can be induced in animal models by 
      injecting the MOG35-55 peptide subcutaneously. Dendritic cells (DCs) that are 
      located at the immunization site phagocytose the MOG35-55 peptide. These DCs 
      mature and migrate into the nearest draining lymph nodes (dLNs), then present 
      antigen, resulting in the activation of naive T cells. T helper type 1 (Th1) and 
      Th17 cells are the primary cells involved in EAE progression. All-trans-retinoic 
      acid (AT-RA) has been shown to have beneficial effects on EAE progression; 
      however, whether AT-RA influences DC maturation or mediates other functions is 
      unclear. In the present study, we showed that AT-RA led to the down-regulation of 
      MHC class II, CD80 (B7-1) and CD86 (B7-2) expressed on the surface of DCs that 
      were isolated from dLNs or spleen 3 days post-immunization in an EAE model. 
      Changes to DC function influenced Th1/Th17 subset polarization. Furthermore, the 
      number of CD44(+) monocytes (which might trigger EAE progression) was also 
      significantly decreased in dLNs, spleen, subarachnoid space and the spinal cord 
      parenchyma after AT-RA treatment. These findings are the first to demonstrate 
      that AT-RA impairs the antigen-presenting capacity of DCs, leading to 
      down-regulation of pathogenic Th1 and Th17 inflammatory cell responses and 
      reducing EAE severity.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Zhan, Xiao-Xia
AU  - Zhan XX
AD  - Department of Neurobiology, Harbin Medical University Provincial Key Laboratory 
      of Neurobiology, Harbin Medical University, Harbin, Heilongjiang, China.
FAU - Liu, Yu
AU  - Liu Y
FAU - Yang, Jin-Feng
AU  - Yang JF
FAU - Wang, Guang-You
AU  - Wang GY
FAU - Mu, Lili
AU  - Mu L
FAU - Zhang, Tong-Shuai
AU  - Zhang TS
FAU - Xie, Xiao-Li
AU  - Xie XL
FAU - Wang, Jing-Hua
AU  - Wang JH
FAU - Liu, Yu-Mei
AU  - Liu YM
FAU - Kong, Qing-Fei
AU  - Kong QF
FAU - Li, Hu-Lun
AU  - Li HL
FAU - Sun, Bo
AU  - Sun B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
RN  - 0 (Antigens, CD)
RN  - 0 (Antioxidants)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Myelin-Oligodendrocyte Glycoprotein)
RN  - 0 (Peptide Fragments)
RN  - 0 (myelin oligodendrocyte glycoprotein (35-55))
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/drug effects
MH  - Antigens, CD/genetics/immunology
MH  - Antioxidants/pharmacology/*therapeutic use
MH  - Cell Differentiation/drug effects
MH  - Dendritic Cells/*drug effects/immunology/pathology
MH  - Encephalomyelitis, Autoimmune, Experimental/chemically induced/*drug 
      therapy/immunology/pathology
MH  - Female
MH  - Gene Expression Regulation/drug effects
MH  - Histocompatibility Antigens Class II/genetics/immunology
MH  - Immunization
MH  - Lymph Nodes/drug effects/immunology/pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Monocytes/*drug effects/immunology/pathology
MH  - Myelin-Oligodendrocyte Glycoprotein
MH  - Peptide Fragments
MH  - Signal Transduction/drug effects
MH  - Spinal Cord/drug effects/immunology/pathology
MH  - Spleen/drug effects/immunology/pathology
MH  - Th1 Cells/drug effects/immunology/pathology
MH  - Th17 Cells/drug effects/immunology/pathology
MH  - Tretinoin/pharmacology/*therapeutic use
PMC - PMC3719944
EDAT- 2012/11/28 06:00
MHDA- 2013/04/27 06:00
PMCR- 2014/04/01
CRDT- 2012/11/28 06:00
PHST- 2012/04/16 00:00 [received]
PHST- 2012/11/15 00:00 [revised]
PHST- 2012/11/16 00:00 [accepted]
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/04/27 06:00 [medline]
PHST- 2014/04/01 00:00 [pmc-release]
AID - 10.1111/imm.12040 [doi]
PST - ppublish
SO  - Immunology. 2013 Apr;138(4):333-45. doi: 10.1111/imm.12040.