PMID- 23181981
OWN - NLM
STAT- MEDLINE
DCOM- 20130228
LR  - 20130108
IS  - 2210-7762 (Print)
VI  - 205
IP  - 12
DP  - 2012 Dec
TI  - A novel TCF3-HLF fusion transcript in acute lymphoblastic leukemia with a 
      t(17;19)(q22;p13).
PG  - 669-72
LID - S2210-7762(12)00254-2 [pii]
LID - 10.1016/j.cancergen.2012.10.004 [doi]
AB  - A 10-year-old boy was admitted to the hospital because of anemia detected after a 
      two week history of fatigue, dizziness, nausea, headaches, and weight loss. A 
      bone marrow investigation confirmed a diagnosis of acute lymphoblastic leukemia 
      of the B-cell precursor phenotype. Chromosome G-banding analysis yielded the 
      karyotype 46,XY,t(17;19)(q22;p13), and fluorescence in situ hybridization (FISH) 
      analysis showed rearrangement of the genes TCF3 (on 19p13; accession number 
      NM_03200 version 3) and HLF (on 17q22; accession number NM_002126 version 4) with 
      the generation of a TCF3-HLF chimera. Polymerase chain reaction and sequencing 
      analyses demonstrated the presence of two in-frame chimeric TCF3-HLF transcripts. 
      In the first one, which corresponds to a type 2 fusion, exon 15 of TCF3 is fused 
      to exon 4 of HLF. In the second, described here for the first time and named type 
      3, exon 14 of TCF3 is fused to exon 4 of HLF. Whether the type 3 chimeric 
      transcript has the same DNA binding and transcriptional regulatory effect as type 
      1 and type 2 TCF3-HLF chimeras remains to be seen.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Panagopoulos, Ioannis
AU  - Panagopoulos I
AD  - Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian 
      Radium Hospital, Oslo University Hospital, Oslo, Norway. 
      ioannis.panagopoulos@rr-research.no
FAU - Micci, Francesca
AU  - Micci F
FAU - Thorsen, Jim
AU  - Thorsen J
FAU - Haugom, Lisbeth
AU  - Haugom L
FAU - Tierens, Anne
AU  - Tierens A
FAU - Ulvmoen, Aina
AU  - Ulvmoen A
FAU - Heim, Sverre
AU  - Heim S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121120
PL  - United States
TA  - Cancer Genet
JT  - Cancer genetics
JID - 101539150
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (RNA, Messenger)
RN  - 0 (TCF3-HLF fusion protein, human)
SB  - IM
MH  - Base Sequence
MH  - Child
MH  - Chromosome Banding
MH  - Chromosomes, Human, Pair 17/*genetics
MH  - Chromosomes, Human, Pair 19/*genetics
MH  - Gene Expression Regulation, Leukemic
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Molecular Sequence Data
MH  - Oncogene Proteins, Fusion/*genetics/metabolism
MH  - Polymerase Chain Reaction
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - RNA, Messenger/genetics/metabolism
MH  - *Translocation, Genetic
EDAT- 2012/11/28 06:00
MHDA- 2013/03/01 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/08/26 00:00 [received]
PHST- 2012/09/26 00:00 [revised]
PHST- 2012/10/05 00:00 [accepted]
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/03/01 06:00 [medline]
AID - S2210-7762(12)00254-2 [pii]
AID - 10.1016/j.cancergen.2012.10.004 [doi]
PST - ppublish
SO  - Cancer Genet. 2012 Dec;205(12):669-72. doi: 10.1016/j.cancergen.2012.10.004. Epub 
      2012 Nov 20.