PMID- 23181982
OWN - NLM
STAT- MEDLINE
DCOM- 20130228
LR  - 20220311
IS  - 2210-7762 (Print)
VI  - 205
IP  - 12
DP  - 2012 Dec
TI  - Epidermal growth factor receptor (EGFR) gene copy number in colorectal 
      adenoma-carcinoma progression.
PG  - 630-5
LID - S2210-7762(12)00255-4 [pii]
LID - 10.1016/j.cancergen.2012.10.005 [doi]
AB  - Adenomas are the easily identifiable precursors of the vast majority of 
      colorectal cancers. Some of their morphological features, such as dysplasia, are 
      predictive of their biological evolution toward adenocarcinomas. A large body of 
      evidence has demonstrated that the epidermal growth factor receptor (EGFR) 
      signaling pathway is commonly activated in colorectal cancer and EGFR-target 
      therapies have improved the outcome for colorectal cancer patients. Nevertheless, 
      the mechanisms underlying the role of EGFR in the adenoma-carcinoma sequence are 
      not entirely clear. We retrospectively analyzed EGFR gene copy number by 
      fluorescence in situ hybridization (FISH) in paraffin-embedded tissue from 215 
      patients recruited through a prospective colorectal cancer screening procedure 
      and undergoing surgical colectomy. We observed that in human colorectal 
      carcinogenesis, EGFR copy number increases progressively, from adenomas with 
      high-grade dysplasia to locally advanced adenocarcinomas, through early invasive 
      adenocarcinomas, suggesting that deregulation of EGFR may correlate with the 
      malignant progression.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Flora, Marcella
AU  - Flora M
AD  - Pathology Unit, Istituto di Ricerca e Cura a Carattere Scientifico 
      (IRCCS)-Arcispedale S. Maria Nuova, Reggio Emilia, Italy.
FAU - Piana, Simonetta
AU  - Piana S
FAU - Bassano, Cristina
AU  - Bassano C
FAU - Bisagni, Alessandra
AU  - Bisagni A
FAU - De Marco, Loredana
AU  - De Marco L
FAU - Ciarrocchi, Alessia
AU  - Ciarrocchi A
FAU - Tagliavini, Elena
AU  - Tagliavini E
FAU - Gardini, Giorgio
AU  - Gardini G
FAU - Tamagnini, Ione
AU  - Tamagnini I
FAU - Banzi, Chiara
AU  - Banzi C
FAU - Bisagni, Giancarlo
AU  - Bisagni G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121120
PL  - United States
TA  - Cancer Genet
JT  - Cancer genetics
JID - 101539150
RN  - EC 2.7.10.1 (EGFR protein, human)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Adenoma/genetics
MH  - Aged
MH  - Colorectal Neoplasms/classification/diagnosis/*genetics/*pathology
MH  - *Disease Progression
MH  - ErbB Receptors/*genetics
MH  - Female
MH  - Follow-Up Studies
MH  - Gene Dosage/*genetics
MH  - Genes, Neoplasm/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Neoplasm Staging
EDAT- 2012/11/28 06:00
MHDA- 2013/03/01 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/02/02 00:00 [received]
PHST- 2012/10/09 00:00 [revised]
PHST- 2012/10/10 00:00 [accepted]
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/03/01 06:00 [medline]
AID - S2210-7762(12)00255-4 [pii]
AID - 10.1016/j.cancergen.2012.10.005 [doi]
PST - ppublish
SO  - Cancer Genet. 2012 Dec;205(12):630-5. doi: 10.1016/j.cancergen.2012.10.005. Epub 
      2012 Nov 20.