PMID- 23182421
OWN - NLM
STAT- MEDLINE
DCOM- 20130607
LR  - 20211021
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Print)
IS  - 0022-3956 (Linking)
VI  - 47
IP  - 2
DP  - 2013 Feb
TI  - Brain-derived neurotrophic factor val66met genotype and early life stress effects 
      upon bipolar course.
PG  - 252-8
LID - S0022-3956(12)00328-7 [pii]
LID - 10.1016/j.jpsychires.2012.10.015 [doi]
AB  - BACKGROUND: Gene-environment interactions may contribute to bipolar disorder (BD) 
      clinical course variability. We examined effects of brain-derived neurotrophic 
      factor (BDNF) val66met genotype and early life stress (ELS) upon illness severity 
      and chronicity in adult BD patients. METHODS: 80 patients (43 BD I, 33 BD II, 4 
      BD not otherwise specified, mean +/- SD age 46.4 +/- 14.0 years, 63.7% female) 
      receiving open evidence-based and measurement-based care in the Stanford Bipolar 
      Disorders Clinic for at least 12 months underwent BDNF val66met genotyping and 
      completed the Childhood Trauma Questionnaire. BDNF met allele carrier genotype 
      and history of childhood sexual and physical abuse were evaluated in relation to 
      mean prior-year Clinical Global Impressions-Bipolar Version-Overall Severity of 
      Illness (MPY-CGI-BP-OS) score and clinical and demographic characteristics. 
      RESULTS: BDNF met allele carriers (but not non-met allele carriers) with compared 
      to without childhood sexual abuse had 21% higher MPY-CGI-BP-OS scores (3.5 +/- 0.7 
      versus 2.9 +/- 0.7, respectively, t = -2.4, df = 28, p = 0.025) and 35% earlier BD 
      onset age (14.6 +/- 5.7 versus 22.8 +/- 7.9 years, respectively, t = 3.0, df = 27, p 
      = 0.006). Regression analysis, however, was non-significant for a BDNF-childhood 
      sexual abuse interaction. LIMITATIONS: small sample of predominantly female 
      Caucasian insured outpatients taking complex medication regimens; only one gene 
      polymorphism considered. CONCLUSIONS: Between group comparisons suggested BDNF 
      met allele carrier genotype might amplify negative effects of ELS upon BD illness 
      severity/chronicity, although with regression analysis, there was not a 
      significant gene-environment interaction. Further studies with larger samples are 
      warranted to assess whether BDNF met allele carriers with ELS are at risk for 
      more severe/chronic BD illness course.
CI  - Published by Elsevier Ltd.
FAU - Miller, Shefali
AU  - Miller S
AD  - Department of Psychiatry and Behavioral Sciences, Stanford University School of 
      Medicine, Stanford, USA. shefalis@stanford.edu
FAU - Hallmayer, Joachim
AU  - Hallmayer J
FAU - Wang, Po W
AU  - Wang PW
FAU - Hill, Shelley J
AU  - Hill SJ
FAU - Johnson, Sheri L
AU  - Johnson SL
FAU - Ketter, Terence A
AU  - Ketter TA
LA  - eng
GR  - L30 MH091787/MH/NIMH NIH HHS/United States
GR  - T32 MH019938/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121123
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Bipolar Disorder/etiology/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Methionine/*genetics
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Psychiatric Status Rating Scales
MH  - Stress, Psychological/complications/genetics
MH  - Valine/*genetics
PMC - PMC3529984
MID - NIHMS419382
EDAT- 2012/11/28 06:00
MHDA- 2013/06/08 06:00
PMCR- 2014/02/01
CRDT- 2012/11/28 06:00
PHST- 2012/06/28 00:00 [received]
PHST- 2012/10/12 00:00 [revised]
PHST- 2012/10/24 00:00 [accepted]
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/06/08 06:00 [medline]
PHST- 2014/02/01 00:00 [pmc-release]
AID - S0022-3956(12)00328-7 [pii]
AID - 10.1016/j.jpsychires.2012.10.015 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2013 Feb;47(2):252-8. doi: 10.1016/j.jpsychires.2012.10.015. 
      Epub 2012 Nov 23.