PMID- 23183370
OWN - NLM
STAT- MEDLINE
DCOM- 20130606
LR  - 20220129
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 160
IP  - 4
DP  - 2013
TI  - Serum total immunoglobulin E is a surrogate of atopy in adult-onset asthma: a 
      longitudinal study.
PG  - 387-92
LID - 10.1159/000342464 [doi]
AB  - BACKGROUND: Studies have shown that serum total immunoglobulin E (IgE) levels are 
      higher in asthmatics. However, the role of the serum total IgE level, 
      independently from atopy, in adult asthma is not understood. We studied the 
      associations between serum total IgE, the number of sensitizations and the sum of 
      specific IgEs and new-onset asthma using longitudinal data from the European 
      Community Respiratory Health Survey. METHODS: Serum total and specific IgE to 4 
      common inhalant allergens were measured at baseline in 9,175 participants, with a 
      follow-up of 9 years. Individuals with asthma history and/or asthma symptoms were 
      excluded. Atopy was defined as the presence of at least one specific IgE >/=0.35 
      kU/l. Total and specific IgEs were regressed against new-onset asthma using 
      multivariate logistic regression with a random intercept for the study centre. 
      RESULTS: Two hundred and ninety-seven participants had developed asthma during 
      follow-up (incidence rate 5.7 per 1,000 person-years). A 10% higher level of 
      total IgE was associated with a 12% increased risk of new-onset asthma (p = 
      0.005). However, after adjustment for the number of positive specific IgEs [odds 
      ratio (OR) for multiple sensitization 1.74, 95% confidence interval (CI) 
      1.05-2.88] and the sum of allergenspecific IgEs (OR 1.18, 95% CI 1.00-1.40), the 
      association between total IgE and asthma disappeared (OR 1.00, 95% CI 0.91-1.10). 
      Seventeen percent of new-onset asthma cases could be attributed to atopy, and 
      this estimate was not largely modified when the total IgE level was 
      simultaneously taken into account. CONCLUSIONS: After taking into account the 
      number and intensity of 4 specific IgEs, the serum total IgE level was not 
      associated with new-onset asthma in adults.
FAU - Carsin, Anne-Elie
AU  - Carsin AE
AD  - Centre for Research in Environmental Epidemiology, Barcelona, Spain. 
      acarsin@creal.cat
FAU - Zock, Jan-Paul
AU  - Zock JP
FAU - Jarvis, Deborah
AU  - Jarvis D
FAU - Basagana, Xavier
AU  - Basagana X
FAU - Heinrich, Joachim
AU  - Heinrich J
FAU - Toren, Kjell
AU  - Toren K
FAU - Janson, Christer
AU  - Janson C
FAU - Anto, Josep Maria
AU  - Anto JM
FAU - Sunyer, Jordi
AU  - Sunyer J
LA  - eng
GR  - G0901214/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121123
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Allergens/*immunology
MH  - Asthma/*immunology
MH  - Female
MH  - Follow-Up Studies
MH  - Health Surveys
MH  - Humans
MH  - Hypersensitivity, Immediate/*immunology
MH  - Immunoglobulin E/*blood/immunology
MH  - Longitudinal Studies
MH  - Male
MH  - Young Adult
EDAT- 2012/11/28 06:00
MHDA- 2013/06/07 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/03/19 00:00 [received]
PHST- 2012/07/30 00:00 [accepted]
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/06/07 06:00 [medline]
AID - 000342464 [pii]
AID - 10.1159/000342464 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2013;160(4):387-92. doi: 10.1159/000342464. Epub 2012 
      Nov 23.