PMID- 2318346
OWN - NLM
STAT- MEDLINE
DCOM- 19900502
LR  - 20190515
IS  - 0012-1797 (Print)
IS  - 0012-1797 (Linking)
VI  - 39
IP  - 4
DP  - 1990 Apr
TI  - Effect of diet on incidence of diabetes in nonobese diabetic mice.
PG  - 432-6
AB  - Nonobese diabetic/Lt mice exhibit a diabetes incidence greater than 70% in 
      females at 30 wk of age. In studies designed to see whether increased dietary 
      carbohydrate, fat, or protein influenced the severity or age at onset of the 
      syndrome, we fed semipurified AIN-76 diet adulterated with increased amounts of 
      these ingredients. Surprisingly, all AIN-76-based diets greatly reduced the 
      expected incidence of diabetes at 30 wk. In addition, a hypoallergenic infant 
      formula, Pregestimil, containing casein hydrolysate in place of protein, 
      completely prevented diabetes up to 1 yr of age. To assess how dietary components 
      might modulate the diabetes incidence, we adulterated standard AIN-76 diet with 
      skim milk, gluten, brewer's yeast, or a natural-ingredient rodent open-formula 
      mouse diet (Old Guilford 96 [OG96]. No increase in diabetes incidence was seen 
      with skim milk (10%) or wheat gluten (10%), whereas brewer's yeast (10%) and OG96 
      (25%) added to AIN-76 increased the incidence compared to mice fed OG96 only. The 
      diabetogenic factor or factors in OG96 could be extracted by chloroform plus 
      methanol (2:1), leaving little activity in the residue. We conclude that diet is 
      a critical factor in diabetes development and that unknown 
      chloroform-methanol-soluble substances in natural-ingredient chow not found in 
      semipurified diets can enhance the development of diabetes in genetically 
      susceptible mice.
FAU - Coleman, D L
AU  - Coleman DL
AD  - Jackson Laboratory, Bar Harbor, Maine 04609.
FAU - Kuzava, J E
AU  - Kuzava JE
FAU - Leiter, E H
AU  - Leiter EH
LA  - eng
GR  - DK-14461/DK/NIDDK NIH HHS/United States
GR  - DK-36175/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
SB  - IM
MH  - Aging
MH  - Animals
MH  - Diabetes Mellitus, Experimental/*etiology/genetics
MH  - *Diet
MH  - Female
MH  - Mice
MH  - Mice, Mutant Strains
MH  - Weight Gain
EDAT- 1990/04/01 00:00
MHDA- 1990/04/01 00:01
CRDT- 1990/04/01 00:00
PHST- 1990/04/01 00:00 [pubmed]
PHST- 1990/04/01 00:01 [medline]
PHST- 1990/04/01 00:00 [entrez]
AID - 10.2337/diab.39.4.432 [doi]
PST - ppublish
SO  - Diabetes. 1990 Apr;39(4):432-6. doi: 10.2337/diab.39.4.432.