PMID- 23183510
OWN - NLM
STAT- MEDLINE
DCOM- 20130409
LR  - 20151119
IS  - 0172-780X (Print)
IS  - 0172-780X (Linking)
VI  - 33 Suppl 2
DP  - 2012
TI  - Relationship of self-reported exercise tolerance with inflammatory markers in 
      women with stable ischemic heart disease.
PG  - 50-4
AB  - OBJECTIVE: Ischemic heart disease (IHD) is associated with decreased exercise 
      tolerance and it is subjectively reported as angina pectoris or dyspnea. 
      Inflammation and pro- inflammatory cytokines are related to progression of IHD, 
      but their level is seldom analyzed in association with self reported exercise 
      tolerance. METHODS: Women aged 35-75 years with stable IHD from Homocysteine 
      Slovakia study (N=175) were analyzed for monocyte chemoatractant protein-1 
      (MCP-1), interleukin 6 (IL-6), transforming growth factor beta1 (TGF beta1), Mannan 
      binding lectin (MBL), heat shock proteins 60 (HSP60), carbonyl protein (CP), high 
      sensitivity C-reactive protein (hsCRP) and oxidized glutathione (GSSG) in 
      relation to exercise induced dyspnea or angina pectoris (AP) (</=200 m). RESULTS: 
      Patients with dyspnea had higher HSP60 (77.3+/-107.2 vs 43.7+/-48.9 ng/ml; p=0.014) 
      and IL-6 (2.9+/-1.3 vs 1.9+/-0.6 pg/ml; p=0.04) levels. IL-6 and HSP60 demonstrated 
      direct correlation with dyspnea (rho=0.39; p=0.02 resp. rho=0.22; p=0.01). AP</=200 
      m patients showed only decreased protein carbonyl a marker of protein oxidation 
      and increased oxidative stress (CP 61.7+/-27.3 vs. 72.1+/-23.1 pg/ml; p=0.001). CP 
      indirectly correlates with AP</=200 m (rho=-0.25; p=0.001). CONCLUSIONS: We have 
      found associations of pro-inflammatory cytokines and inflammation markers with 
      dyspnea or angina pectoris, but the relationship was not consistent in our 
      patients with stable ischemic heart disease.
FAU - Lietava, Jan
AU  - Lietava J
AD  - 2nd Department of Internal Medicine, Comenius University, Bratislava, Slovakia. 
      jan.lietava@yahoo.com
FAU - Vohnout, Branislav
AU  - Vohnout B
FAU - Penz, Peter
AU  - Penz P
FAU - Kuka, Peter
AU  - Kuka P
FAU - Bucova, Maria
AU  - Bucova M
FAU - Kosmalova, Viera
AU  - Kosmalova V
FAU - Atalay, Mustafa
AU  - Atalay M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Sweden
TA  - Neuro Endocrinol Lett
JT  - Neuro endocrinology letters
JID - 8008373
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chaperonin 60)
RN  - 0 (Chemokine CCL2)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Mannose-Binding Lectin)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - ULW86O013H (Glutathione Disulfide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Angina, Stable/blood/*immunology/*physiopathology
MH  - Biomarkers/blood
MH  - C-Reactive Protein/metabolism
MH  - Chaperonin 60/blood
MH  - Chemokine CCL2/blood
MH  - Dyspnea/blood/immunology/physiopathology
MH  - Exercise Tolerance/*immunology
MH  - Female
MH  - Glutathione Disulfide/blood
MH  - Humans
MH  - Interleukin-6/blood
MH  - Mannose-Binding Lectin/blood
MH  - Middle Aged
MH  - Myocardial Ischemia/blood/*immunology/*physiopathology
MH  - Transforming Growth Factor beta1/blood
EDAT- 2012/11/28 06:00
MHDA- 2013/04/10 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/10/15 00:00 [received]
PHST- 2012/11/12 00:00 [accepted]
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/04/10 06:00 [medline]
AID - NEL330812A10 [pii]
PST - ppublish
SO  - Neuro Endocrinol Lett. 2012;33 Suppl 2:50-4.