PMID- 23184341
OWN - NLM
STAT- MEDLINE
DCOM- 20130523
LR  - 20211021
IS  - 1179-2000 (Electronic)
IS  - 1177-1062 (Linking)
VI  - 16
IP  - 6
DP  - 2012 Dec
TI  - Cardiac troponins I and T: molecular markers for early diagnosis, prognosis, and 
      accurate triaging of patients with acute myocardial infarction.
PG  - 371-81
LID - 10.1007/s40291-012-0011-6 [doi]
AB  - Acute myocardial infarction (AMI) is the leading cause of death worldwide, with 
      early diagnosis still being difficult. Promising new cardiac biomarkers such as 
      troponins and creatine kinase (CK) isoforms are being studied and integrated into 
      clinical practice for early diagnosis of AMI. The cardiac-specific troponins I 
      and T (cTnI and cTnT) have good sensitivity and specificity as indicators of 
      myocardial necrosis and are superior to CK and its MB isoenzyme (CK-MB) in this 
      regard. Besides being potential biologic markers, cardiac troponins also provide 
      significant prognostic information. The introduction of novel high-sensitivity 
      troponin assays has enabled more sensitive and timely diagnosis or exclusion of 
      acute coronary syndromes. This review summarizes the available information on the 
      potential of troponins and other cardiac markers in early diagnosis and prognosis 
      of AMI, and provides perspectives on future diagnostic approaches to AMI.
FAU - Tiwari, Ram P
AU  - Tiwari RP
AD  - Diagnostic Division, RFCL Limited (formerly Ranbaxy Fine Chemicals Limited), 
      Avantor Performance Materials, New Delhi, India.
FAU - Jain, Anubhav
AU  - Jain A
FAU - Khan, Zakir
AU  - Khan Z
FAU - Kohli, Veena
AU  - Kohli V
FAU - Bharmal, R N
AU  - Bharmal RN
FAU - Kartikeyan, S
AU  - Kartikeyan S
FAU - Bisen, Prakash S
AU  - Bisen PS
LA  - eng
PT  - Journal Article
PT  - Review
PL  - New Zealand
TA  - Mol Diagn Ther
JT  - Molecular diagnosis & therapy
JID - 101264260
RN  - 0 (Biomarkers)
RN  - 0 (Troponin I)
RN  - 0 (Troponin T)
SB  - IM
MH  - *Biomarkers/analysis/blood/metabolism
MH  - Early Diagnosis
MH  - Humans
MH  - Molecular Diagnostic Techniques/methods/standards
MH  - Myocardial Infarction/blood/*classification/*diagnosis/therapy
MH  - Myocardium/metabolism
MH  - Prognosis
MH  - Sensitivity and Specificity
MH  - Triage/*methods
MH  - Troponin I/analysis/blood/metabolism/*physiology
MH  - Troponin T/analysis/blood/metabolism/*physiology
EDAT- 2012/11/28 06:00
MHDA- 2013/05/25 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/05/25 06:00 [medline]
AID - 10.1007/s40291-012-0011-6 [doi]
PST - ppublish
SO  - Mol Diagn Ther. 2012 Dec;16(6):371-81. doi: 10.1007/s40291-012-0011-6.