PMID- 23184486
OWN - NLM
STAT- MEDLINE
DCOM- 20131227
LR  - 20211021
IS  - 1874-9356 (Electronic)
IS  - 0015-5632 (Print)
IS  - 0015-5632 (Linking)
VI  - 58
IP  - 4
DP  - 2013 Jul
TI  - HLA-C, DRB1 and DQB1 alleles involved in genetic predisposition to psoriasis 
      vulgaris in the Slovak population.
PG  - 319-24
LID - 10.1007/s12223-012-0213-7 [doi]
AB  - Psoriasis vulgaris is a complex chronic skin disease with immunological and 
      genetic background. The most important predisposing genetic factors in psoriasis 
      are genes of the human leukocyte antigen (HLA) region. Accumulative evidence has 
      shown that several HLA alleles are closely associated with psoriasis; however, 
      they tend to vary in different racial and ethnic backgrounds. One hundred 
      forty-seven unrelated Slovak patients with psoriasis vulgaris (average age at 
      onset 28 +/- 14 years) were genotyped for the HLA-C, DQB1 and DRB1 alleles by the 
      polymerase chain reaction using sequence-specific primers. Allele frequencies 
      observed in the group of psoriatic patients were compared to those obtained in 
      the ethnically matched control group comprising 194 subjects with no history of 
      psoriasis. Susceptibility to psoriasis vulgaris in our study group is 
      significantly associated with HLA-C*06 (odds ratio (OR) = 3.85), DRB1*07 
      (OR = 2.56) and DQB1*02 (OR = 1.09), respectively, whereas DRB*01 (OR = 0.05) is 
      associated negatively. Hereby, we provide the first report on the association of 
      HLA-C, DRB1 and DQB1 alleles with psoriasis in the Slovak population. Our 
      findings confirm HLA-C*06 and DRB1*07 as the most important genetic risk factors 
      for psoriasis. However, the role of HLA genes as causative in the pathogenesis of 
      the disease remains unclear. Identification of genetic factors that increase the 
      risk of psoriasis is a precondition that helps to elucidate the pathogenesis of 
      this troubling disease and identify targets for a more specific and effective 
      therapy.
FAU - Shawkatova, Ivana
AU  - Shawkatova I
AD  - Department of Immunology, Comenius University School of Medicine, Nam. odborarov 
      14, Bratislava, Slovakia. ivana.shawkatova@fmed.uniba.sk
FAU - Javor, Juraj
AU  - Javor J
FAU - Parnicka, Zuzana
AU  - Parnicka Z
FAU - Kozub, Peter
AU  - Kozub P
FAU - Zilinkova, Maria
AU  - Zilinkova M
FAU - Frey, Peter
AU  - Frey P
FAU - Ferencik, Stanislav
AU  - Ferencik S
FAU - Buc, Milan
AU  - Buc M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121127
PL  - United States
TA  - Folia Microbiol (Praha)
JT  - Folia microbiologica
JID - 0376757
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-C Antigens/*genetics
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Polymerase Chain Reaction
MH  - Psoriasis/*genetics
MH  - Slovakia
PMC - PMC3683150
EDAT- 2012/11/28 06:00
MHDA- 2013/12/29 06:00
PMCR- 2012/11/27
CRDT- 2012/11/28 06:00
PHST- 2012/07/08 00:00 [received]
PHST- 2012/11/11 00:00 [accepted]
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/12/29 06:00 [medline]
PHST- 2012/11/27 00:00 [pmc-release]
AID - 213 [pii]
AID - 10.1007/s12223-012-0213-7 [doi]
PST - ppublish
SO  - Folia Microbiol (Praha). 2013 Jul;58(4):319-24. doi: 10.1007/s12223-012-0213-7. 
      Epub 2012 Nov 27.