PMID- 23184535
OWN - NLM
STAT- MEDLINE
DCOM- 20130916
LR  - 20231115
IS  - 1552-485X (Electronic)
IS  - 1552-4841 (Print)
IS  - 1552-4841 (Linking)
VI  - 162B
IP  - 1
DP  - 2013 Jan
TI  - No association of genetic variants in BDNF with major depression: a meta- and 
      gene-based analysis.
PG  - 61-70
LID - 10.1002/ajmg.b.32122 [doi]
AB  - Major depressive disorder (MDD) is a complex psychiatric condition with strong 
      genetic predisposition. The association of MDD with genetic polymorphisms, such 
      as Val66Met (rs6265), in the brain derived neurotrophic factor (BDNF), have been 
      reported in many studies and the results were conflicting. In this study, we 
      performed a systematic literature search and conducted random-effects 
      meta-analysis to evaluate genetic variants in BDNF with MDD. A gene-based 
      analysis was also conducted to investigate the cumulative effects of genetic 
      polymorphisms in BDNF. A total of 28 studies from 26 published articles were 
      included in our analysis. Meta-analysis yielded an estimated odds ratio (OR) of 
      0.96 (95% CI: 0.89-1.05; P = 0.402) for Val66Met (rs6265), 0.83 (95% CI: 
      0.67-1.04; P = 0.103) for 11757C/G, 1.16 (95% CI: 0.74-1.82; P = 0.527) for 
      270T/C, 1.03 (95% CI: 0.18-5.75; P = 0.974) for 712A/G and 0.98 (95% CI: 
      0.85-1.14; P = 0.831) for rs988748. The gene-based analysis indicated that BDNF 
      is not associated with MDD (P > 0.21). Our updated meta- and novel gene-based 
      analyses provide no evidence of the association of BDNF with major depression.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Gyekis, Joseph P
AU  - Gyekis JP
AD  - Department of Biobehavioral Health, Pennsylvania State University, State College, 
      PA 16801, USA.
FAU - Yu, Weihong
AU  - Yu W
FAU - Dong, Shuqian
AU  - Dong S
FAU - Wang, Haina
AU  - Wang H
FAU - Qian, Jun
AU  - Qian J
FAU - Kota, Pravina
AU  - Kota P
FAU - Yang, Jingyun
AU  - Yang J
LA  - eng
GR  - G0902227/MRC_/Medical Research Council/United Kingdom
GR  - P50 DA010075/DA/NIDA NIH HHS/United States
GR  - P50DA010075-16/DA/NIDA NIH HHS/United States
GR  - MR/K013041/1/MRC_/Medical Research Council/United Kingdom
GR  - MC_G1000733/MRC_/Medical Research Council/United Kingdom
GR  - G0900688/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, N.I.H., Extramural
DEP - 20121126
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the 
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Amino Acid Substitution/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Depressive Disorder, Major/*genetics
MH  - *Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Middle Aged
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Publication Bias
PMC - PMC3725128
MID - NIHMS491283
EDAT- 2012/11/28 06:00
MHDA- 2013/09/17 06:00
PMCR- 2014/01/01
CRDT- 2012/11/28 06:00
PHST- 2012/05/25 00:00 [received]
PHST- 2012/11/05 00:00 [accepted]
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/09/17 06:00 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.1002/ajmg.b.32122 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2013 Jan;162B(1):61-70. doi: 
      10.1002/ajmg.b.32122. Epub 2012 Nov 26.