PMID- 23185198
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121128
LR  - 20211021
IS  - 1896-9151 (Electronic)
IS  - 1734-1922 (Print)
IS  - 1734-1922 (Linking)
VI  - 8
IP  - 5
DP  - 2012 Nov 9
TI  - HLA-DR, HLA-DQB1 and PTPN22 gene polymorphism: association with age at onset for 
      autoimmune diabetes.
PG  - 874-8
LID - 10.5114/aoms.2012.31619 [doi]
AB  - INTRODUCTION: Autoimmune diabetes has different clinical manifestations related 
      to the age at onset. It is divided into several subtypes, including "classical" 
      type 1 diabetes (T1D) and latent autoimmune diabetes in adults (LADA). The LADA 
      is considered a slowly progressing subtype of autoimmune diabetes, although the 
      clinical picture is more similar to type 2 diabetes. MATERIAL AND METHODS: The 
      aim of this study is to investigate whether genetic predisposition influences age 
      at onset in autoimmune diabetes. We studied rs2476601 PTPN22 gene polymorphism 
      and HLA DR, HLA-DQB1 in 175 patients with classical type 1 diabetes, 80 LADA, and 
      151 control subjects from north-east Poland. RESULTS: The frequencies of the 
      PTPN22 TT genotype were higher in the group of patients with classical type 1 
      diabetes (6.3%) and LADA (11.3%) than in control subjects (0.7%) (p = 0.02 and p 
      = 0007, respectively). In patients with classical type 1 diabetes we observed an 
      increasing trend in frequencies of genotype TT dependent on age at onset (3.9% 
      (0-5 year olds), 6.0% (6-15 year-olds), 8.2% (16-25 year olds), p = 0.048). The 
      incidence of predisposing human leukocyte antigen (HLA) genotypes HLA DR3/DQB1*02 
      and DR4/DQB1*0302 was found to decrease in the group with type 1 diabetes in 
      relation to age at onset and LADA (HLA DR3/DQB1*02 - 69.2% (0-5 year olds), 57.0% 
      (6-15 year olds), 51.0% (16-25 year olds), 46.3% (LADA), p = 0.032; HLA 
      DR4/DQB1*0302 - 80.8% (0-5 year olds), 63.0% (6-15 year olds), 51.0% (16-25 year 
      olds), 43.8% (LADA), p = 0.0003), and to increase for the protective allele 
      DQB1*0602 (0.0% (0-5 year olds), 1.0% (6-15 year olds), 2.0% (16-25 year olds), 
      6.3% (LADA), p = 0.029). CONCLUSIONS: Thus, age at onset for autoimmune diabetes 
      appears to be related to a combination of predisposing and protective HLA 
      alleles. Against a background of HLA genetic predisposition, other non-HLA loci 
      may influence age at onset for late autoimmune diabetes.
FAU - Okruszko, Anna
AU  - Okruszko A
AD  - Department of Endocrinology, Diabetology and Internal Medicine, Medical 
      University of Bialystok, Poland.
FAU - Szepietowska, Barbara
AU  - Szepietowska B
FAU - Wawrusiewicz-Kurylonek, Natalia
AU  - Wawrusiewicz-Kurylonek N
FAU - Gorska, Maria
AU  - Gorska M
FAU - Kretowski, Adam
AU  - Kretowski A
FAU - Szelachowska, Malgorzata
AU  - Szelachowska M
LA  - eng
PT  - Journal Article
DEP - 20121107
PL  - Poland
TA  - Arch Med Sci
JT  - Archives of medical science : AMS
JID - 101258257
PMC - PMC3506241
OTO - NOTNLM
OT  - HLA
OT  - PTPN22
OT  - latent autoimmune diabetes in adults
OT  - type 1 diabetes
EDAT- 2012/11/28 06:00
MHDA- 2012/11/28 06:01
PMCR- 2012/11/09
CRDT- 2012/11/28 06:00
PHST- 2012/05/30 00:00 [received]
PHST- 2012/07/12 00:00 [revised]
PHST- 2012/08/20 00:00 [accepted]
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2012/11/28 06:01 [medline]
PHST- 2012/11/09 00:00 [pmc-release]
AID - 19712 [pii]
AID - 10.5114/aoms.2012.31619 [doi]
PST - ppublish
SO  - Arch Med Sci. 2012 Nov 9;8(5):874-8. doi: 10.5114/aoms.2012.31619. Epub 2012 Nov 
      7.