PMID- 23185492
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 11
DP  - 2012
TI  - Differential involvement of brain-derived neurotrophic factor in reconsolidation 
      and consolidation of conditioned taste aversion memory.
PG  - e49942
LID - 10.1371/journal.pone.0049942 [doi]
LID - e49942
AB  - Consolidated memory can re-enter states of transient instability following 
      reactivation, which is referred to as reconsolidation, and the exact molecular 
      mechanisms underlying this process remain unexplored. Brain-derived neurotrophic 
      factor (BDNF) plays a critical role in synaptic plasticity and memory processes. 
      We have recently observed that BDNF signaling in the central nuclei of the 
      amygdala (CeA) and insular cortex (IC) was involved in the consolidation of 
      conditioned taste aversion (CTA) memory. However, whether BDNF in the CeA or IC 
      is required for memory reconsolidation is still unclear. In the present study, 
      using a CTA memory paradigm, we observed increased BDNF expression in the IC but 
      not in the CeA during CTA reconsolidation. We further determined that BDNF 
      synthesis and signaling in the IC but not in the CeA was required for memory 
      reconsolidation. The differential, spatial-specific roles of BDNF in memory 
      consolidation and reconsolidation suggest that dissociative molecular mechanisms 
      underlie reconsolidation and consolidation, which might provide novel targets for 
      manipulating newly encoded and reactivated memories without causing universal 
      amnesia.
FAU - Wang, Yue
AU  - Wang Y
AD  - Department of Neurobiology, Shandong Provincial Key Laboratory of Mental 
      Disorders, School of Medicine, Shandong University, Jinan, Shandong, People's 
      Republic of China.
FAU - Zhang, Tian-Yi
AU  - Zhang TY
FAU - Xin, Jian
AU  - Xin J
FAU - Li, Ting
AU  - Li T
FAU - Yu, Hui
AU  - Yu H
FAU - Li, Na
AU  - Li N
FAU - Chen, Zhe-Yu
AU  - Chen ZY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121121
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - *Brain-Derived Neurotrophic Factor/metabolism/physiology
MH  - *Cerebral Cortex/metabolism/physiology
MH  - Conditioning, Classical/physiology
MH  - Memory/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Synapses/metabolism/physiology
MH  - Taste/*physiology
PMC - PMC3503816
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2012/11/28 06:00
MHDA- 2013/06/01 06:00
PMCR- 2012/11/21
CRDT- 2012/11/28 06:00
PHST- 2012/07/02 00:00 [received]
PHST- 2012/10/17 00:00 [accepted]
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
PHST- 2012/11/21 00:00 [pmc-release]
AID - PONE-D-12-19878 [pii]
AID - 10.1371/journal.pone.0049942 [doi]
PST - ppublish
SO  - PLoS One. 2012;7(11):e49942. doi: 10.1371/journal.pone.0049942. Epub 2012 Nov 21.