PMID- 23187008
OWN - NLM
STAT- MEDLINE
DCOM- 20130806
LR  - 20211021
IS  - 1976-670X (Electronic)
IS  - 1976-6696 (Print)
IS  - 1976-6696 (Linking)
VI  - 45
IP  - 11
DP  - 2012 Nov
TI  - Effects of chronic caloric restriction on kidney and heart redox status and 
      antioxidant enzyme activities in Wistar rats.
PG  - 671-6
AB  - Caloric restriction (CR) has been associated with health benefits and these 
      effects have been attributed, in part, to modulation of oxidative status by CR; 
      however, data are still controversial. Here, we investigate the effects of 
      seventeen weeks of chronic CR on parameters of oxidative damage/ modification of 
      proteins and on antioxidant enzyme activities in cardiac and kidney tissues. Our 
      results demonstrate that CR induced an increase in protein carbonylation in the 
      heart without changing the content of sulfhydryl groups or the activities of 
      superoxide dismutase and catalase (CAT). Moreover, CR caused an increase in CAT 
      activity in kidney, without changing other parameters. Protein carbonylation has 
      been associated with oxidative damage and functional impairment; however, we 
      cannot exclude the possibility that, under our conditions, this alteration 
      indicates a different functional meaning in the heart tissue. In addition, we 
      reinforce the idea that CR can increase CAT activity in the kidney.
FAU - Dutra, Marcio Ferreira
AU  - Dutra MF
AD  - Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade 
      Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. marciodutra5@yahoo.com.br
FAU - Bristot, Ivi Juliana
AU  - Bristot IJ
FAU - Batassini, Cristiane
AU  - Batassini C
FAU - Cunha, Nubia Broetto
AU  - Cunha NB
FAU - Vizuete, Adriana Fernanda Kuckartz
AU  - Vizuete AF
FAU - de Souza, Daniela Fraga
AU  - de Souza DF
FAU - Moreira, Jose Claudio Fonseca
AU  - Moreira JC
FAU - Goncalves, Carlos-Alberto
AU  - Goncalves CA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - BMB Rep
JT  - BMB reports
JID - 101465334
RN  - 0 (Antioxidants)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Animals
MH  - Antioxidants/*metabolism
MH  - *Caloric Restriction
MH  - Catalase/metabolism
MH  - Heart/*physiopathology
MH  - Kidney/*physiopathology
MH  - Male
MH  - Oxidation-Reduction
MH  - *Oxidative Stress
MH  - Protein Carbonylation
MH  - Rats
MH  - Rats, Wistar
MH  - Superoxide Dismutase/metabolism
PMC - PMC4133804
EDAT- 2012/11/29 06:00
MHDA- 2013/08/07 06:00
PMCR- 2012/12/01
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2013/08/07 06:00 [medline]
PHST- 2012/12/01 00:00 [pmc-release]
AID - BMB-45-671 [pii]
AID - 10.5483/bmbrep.2012.45.11.094 [doi]
PST - ppublish
SO  - BMB Rep. 2012 Nov;45(11):671-6. doi: 10.5483/bmbrep.2012.45.11.094.