PMID- 23187122
OWN - NLM
STAT- MEDLINE
DCOM- 20130204
LR  - 20220409
IS  - 1558-8238 (Electronic)
IS  - 0021-9738 (Print)
IS  - 0021-9738 (Linking)
VI  - 122
IP  - 12
DP  - 2012 Dec
TI  - Gastric bypass and banding equally improve insulin sensitivity and beta cell 
      function.
PG  - 4667-74
LID - 64895 [pii]
LID - 10.1172/JCI64895 [doi]
AB  - Bariatric surgery in obese patients is a highly effective method of preventing or 
      resolving type 2 diabetes mellitus (T2DM); however, the remission rate is not the 
      same among different surgical procedures. We compared the effects of 20% weight 
      loss induced by laparoscopic adjustable gastric banding (LAGB) or Roux-en-Y 
      gastric bypass (RYGB) surgery on the metabolic response to a mixed meal, insulin 
      sensitivity, and beta cell function in nondiabetic obese adults. The metabolic 
      response to meal ingestion was markedly different after RYGB than after LAGB 
      surgery, manifested by rapid delivery of ingested glucose into the systemic 
      circulation, by an increase in the dynamic insulin secretion rate, and by large, 
      early postprandial increases in plasma glucose, insulin, and glucagon-like 
      peptide-1 concentrations in the RYGB group. However, the improvement in oral 
      glucose tolerance, insulin sensitivity, and overall beta cell function after weight 
      loss were not different between surgical groups. Additionally, both surgical 
      procedures resulted in a similar decrease in adipose tissue markers of 
      inflammation. We conclude that marked weight loss itself is primarily responsible 
      for the therapeutic effects of RYGB and LAGB on insulin sensitivity, beta cell 
      function, and oral glucose tolerance in nondiabetic obese adults.
FAU - Bradley, David
AU  - Bradley D
AD  - Center for Human Nutrition, Washington University School of Medicine, St. Louis, 
      Missouri 63110, USA.
FAU - Conte, Caterina
AU  - Conte C
FAU - Mittendorfer, Bettina
AU  - Mittendorfer B
FAU - Eagon, J Christopher
AU  - Eagon JC
FAU - Varela, J Esteban
AU  - Varela JE
FAU - Fabbrini, Elisa
AU  - Fabbrini E
FAU - Gastaldelli, Amalia
AU  - Gastaldelli A
FAU - Chambers, Kari T
AU  - Chambers KT
FAU - Su, Xiong
AU  - Su X
FAU - Okunade, Adewole
AU  - Okunade A
FAU - Patterson, Bruce W
AU  - Patterson BW
FAU - Klein, Samuel
AU  - Klein S
LA  - eng
GR  - T32 HL007456/HL/NHLBI NIH HHS/United States
GR  - DK 37948/DK/NIDDK NIH HHS/United States
GR  - P30 DK056341/DK/NIDDK NIH HHS/United States
GR  - UL1 RR024992/RR/NCRR NIH HHS/United States
GR  - UL1 TR000448/TR/NCATS NIH HHS/United States
GR  - R01 DK037948/DK/NIDDK NIH HHS/United States
GR  - RR-00954/RR/NCRR NIH HHS/United States
GR  - P30 DK020579/DK/NIDDK NIH HHS/United States
GR  - DK 56341/DK/NIDDK NIH HHS/United States
GR  - P41 RR000954/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121126
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
RN  - 0 (ADGRE1 protein, human)
RN  - 0 (CD11b Antigen)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Ceramides)
RN  - 0 (Cytokines)
RN  - 0 (Diglycerides)
RN  - 0 (ITGAM protein, human)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Insulin)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Mucins)
RN  - 0 (Receptors, G-Protein-Coupled)
SB  - IM
MH  - Adult
MH  - Area Under Curve
MH  - Body Composition
MH  - CD11b Antigen/metabolism
MH  - Calcium-Binding Proteins
MH  - Ceramides/metabolism
MH  - Cytokines/metabolism
MH  - Diglycerides/metabolism
MH  - Female
MH  - *Gastric Bypass
MH  - *Gastroplasty
MH  - Humans
MH  - Inflammation Mediators/metabolism
MH  - Insulin/metabolism
MH  - *Insulin Resistance
MH  - Insulin Secretion
MH  - Insulin-Secreting Cells/metabolism/*physiology
MH  - Intra-Abdominal Fat/metabolism/pathology
MH  - Male
MH  - Membrane Glycoproteins/metabolism
MH  - Middle Aged
MH  - Mucins/metabolism
MH  - Muscle, Skeletal/metabolism
MH  - Obesity/metabolism/pathology/*surgery
MH  - Organ Size
MH  - Postprandial Period
MH  - Receptors, G-Protein-Coupled/metabolism
MH  - Weight Loss
PMC - PMC3512168
EDAT- 2012/11/29 06:00
MHDA- 2013/02/05 06:00
PMCR- 2012/11/26
CRDT- 2012/11/29 06:00
PHST- 2012/05/21 00:00 [received]
PHST- 2012/09/06 00:00 [accepted]
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
PHST- 2012/11/26 00:00 [pmc-release]
AID - 64895 [pii]
AID - 10.1172/JCI64895 [doi]
PST - ppublish
SO  - J Clin Invest. 2012 Dec;122(12):4667-74. doi: 10.1172/JCI64895. Epub 2012 Nov 26.