PMID- 23188186
OWN - NLM
STAT- MEDLINE
DCOM- 20131206
LR  - 20211021
IS  - 1349-9157 (Electronic)
IS  - 0449-3060 (Print)
IS  - 0449-3060 (Linking)
VI  - 54
IP  - 3
DP  - 2013 May
TI  - Volumetric intensity-modulated arc therapy vs conventional intensity-modulated 
      radiation therapy in nasopharyngeal carcinoma: a dosimetric study.
PG  - 532-45
LID - 10.1093/jrr/rrs111 [doi]
AB  - Dosimetric comparisons between RapidArc (RA) and conventional Intensity-Modulated 
      Radiation Therapy (IMRT) techniques for nasopharyngeal carcinoma (NPC) were 
      performed to address differences in dose coverage of the target, sparing of 
      organs-at-risk (OARs), delivery of monitor units (MUs) and time, to assess 
      whether the RA technique was more beneficial for treatment of NPC. Eight NPC 
      patients (Stages I-IV), who had completed RA treatment, were selected for this 
      study. Computed tomography data sets were re-planned using 7-fields fixed beam 
      IMRT. Quantitative measurements of dose-endpoint values on the dose-volume 
      histograms were carried out for evaluation of: (i) dose homogeneity (D5% - 
      D(95%)); (ii) degree of conformity (CI9(5%)); (iii) tumor control probability 
      (TCP); (iv) doses to OARs; (v) normal tissue complication probability (NTCP); 
      (vi) treatment time; and (vii) MUs. RA plans achieved better dose conformity and 
      TCP in planning target volumes (PTVs). Target dose homogeneity was not as high as 
      for IMRT plans. Doses to tempero-mandibular joints, clavicles, parotid glands and 
      posterior neck, and their NTCPs were significantly lower in RA plans (P < 0.05). 
      Mean doses to the brainstem and spinal cord were slightly lower in IMRT plans. RA 
      plans allowed for a mean reduction in MUs by 78% (P = 0.006), and a four-fold 
      reduction in treatment delivery times, relative to IMRT plans. RA plans showed 
      superior, or comparable, target coverage and dose conformity in PTVs, but at the 
      expense of inferior dose homogeneity. RA plans also achieved significant 
      improvements in dose reduction to OARs and healthy tissue sparing. A significant 
      reduction in treatment delivery time for RA treatment technique was also noted.
FAU - White, Peter
AU  - White P
AD  - Department of Health Technology and Informatics, The Hong Kong Polytechnic 
      University, Hung Hom, Kowloon, Hong Kong. htpwhite@polyu.edu.hk
FAU - Chan, Kit Chi
AU  - Chan KC
FAU - Cheng, Ka Wai
AU  - Cheng KW
FAU - Chan, Ka Yiu
AU  - Chan KY
FAU - Chau, Ming Chun
AU  - Chau MC
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121127
PL  - England
TA  - J Radiat Res
JT  - Journal of radiation research
JID - 0376611
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nasopharyngeal Neoplasms/*radiotherapy
MH  - Organs at Risk/radiation effects
MH  - Radiation Injuries/*etiology/*prevention & control
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Radiotherapy, Intensity-Modulated/*adverse effects/*methods
MH  - Treatment Outcome
MH  - Whole-Body Counting/*methods
PMC - PMC3650737
OTO - NOTNLM
OT  - IMRT
OT  - RapidArc
OT  - dosimetry
OT  - nasopharyngeal carcinoma
OT  - planning
EDAT- 2012/11/29 06:00
MHDA- 2013/12/16 06:00
PMCR- 2012/11/27
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PHST- 2012/11/27 00:00 [pmc-release]
AID - rrs111 [pii]
AID - 10.1093/jrr/rrs111 [doi]
PST - ppublish
SO  - J Radiat Res. 2013 May;54(3):532-45. doi: 10.1093/jrr/rrs111. Epub 2012 Nov 27.