PMID- 23189153
OWN - NLM
STAT- MEDLINE
DCOM- 20130516
LR  - 20220321
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 11
DP  - 2012
TI  - Status of systemic oxidative stresses in patients with primary open-angle 
      glaucoma and pseudoexfoliation syndrome.
PG  - e49680
LID - 10.1371/journal.pone.0049680 [doi]
LID - e49680
AB  - BACKGROUND: The involvement of local and systemic oxidative stress in intraocular 
      pressure (IOP) elevation and optic nerve damage has been hypothesized in the 
      pathogenesis of glaucoma. To test this, we measured the systemic levels of 
      prooxidants and antioxidants by analyzing the blood biochemistry in patients with 
      glaucoma. METHODS: Peripheral blood samples were collected from Japanese patients 
      with primary open-angle glaucoma (PG) (n = 206), exfoliation syndrome (EX) 
      (n = 199), and controls (n = 126). Plasma levels of lipid peroxides, 
      ferric-reducing activity, and thiol antioxidant activity were measured by diacron 
      reactive oxygen metabolites (dROM), biological antioxidant potential (BAP), and 
      sulfhydryl (SH) tests, respectively, using a free radical analyzer. RESULTS: In 
      the PG, EX, and control groups, the mean +/- standard deviation values were 355+/-63, 
      357+/-69, and 348+/-56 (U. Carr), respectively, for dROM; 1,951+/-282, 1,969+/-252, and 
      2,033+/-252 (micromol/L), respectively, for BAP (micromol/L); and 614+/-98, 584+/-91, and 
      617+/-99 (micromol/L), respectively, for SH. The differences in the BAP values were 
      significant between the PG and control groups (p = 0.0062), for SH between the EX 
      and control groups (p = 0.0017), and for SH between the PG and EX groups 
      (p = 0.0026). After adjustment for differences in age and sex among groups using 
      multiple regression analysis, lower BAP values were correlated significantly with 
      PG (p = 0.0155) and EX (p = 0.0049). Higher dROM values with and without glaucoma 
      were correlated with female gender, and lower SH values with older age. There 
      were no significant differences between the higher (>/=21 mmHg) and lower (<21 
      mmHg) baseline IOPs in the PG group or between the presence or absence of 
      glaucoma in the EX group. CONCLUSIONS: Lower systemic antioxidant capacity that 
      measured by ferric-reducing activity is involved in the pathogenesis of PG and 
      EX.
FAU - Tanito, Masaki
AU  - Tanito M
AD  - Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo, 
      Shimane, Japan. tanito-oph@umin.ac.jp
FAU - Kaidzu, Sachiko
AU  - Kaidzu S
FAU - Takai, Yasuyuki
AU  - Takai Y
FAU - Ohira, Akihiro
AU  - Ohira A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121126
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Antioxidants)
RN  - 0 (Sulfhydryl Compounds)
RN  - BBX060AN9V (Hydrogen Peroxide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antioxidants/metabolism
MH  - Exfoliation Syndrome/blood/*metabolism
MH  - Female
MH  - Glaucoma, Open-Angle/blood/*metabolism
MH  - Humans
MH  - Hydrogen Peroxide/blood
MH  - Male
MH  - Middle Aged
MH  - *Oxidative Stress
MH  - Sulfhydryl Compounds/blood
MH  - Young Adult
PMC - PMC3506654
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2012/11/29 06:00
MHDA- 2013/05/17 06:00
PMCR- 2012/11/26
CRDT- 2012/11/29 06:00
PHST- 2012/06/22 00:00 [received]
PHST- 2012/10/12 00:00 [accepted]
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
PHST- 2012/11/26 00:00 [pmc-release]
AID - PONE-D-12-18358 [pii]
AID - 10.1371/journal.pone.0049680 [doi]
PST - ppublish
SO  - PLoS One. 2012;7(11):e49680. doi: 10.1371/journal.pone.0049680. Epub 2012 Nov 26.