PMID- 23189980
OWN - NLM
STAT- MEDLINE
DCOM- 20131104
LR  - 20220331
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 37
IP  - 4
DP  - 2013 Feb
TI  - BDNF-mediated regulation of ethanol consumption requires the activation of the 
      MAP kinase pathway and protein synthesis.
PG  - 607-12
LID - 10.1111/ejn.12067 [doi]
AB  - We previously found that the brain-derived neurotrophic factor (BDNF) in the 
      dorsolateral striatum (DLS) is part of a homeostatic pathway that gates ethanol 
      self-administration [Jeanblanc et al. (2009). J Neurosci, 29, 13494-13502)]. 
      Specifically, we showed that moderate levels (10%) of ethanol consumption 
      increase BDNF expression within the DLS, and that direct infusion of BDNF into 
      the DLS decreases operant self-administration of a 10% ethanol solution. BDNF 
      binding to its receptor, TrkB, activates the mitogen-activated protein kinase 
      (MAPK), phospholipase C-gamma (PLC-gamma) and phosphatidylinositol 3-kinase (PI3K) 
      pathways. Thus, here, we set out to identify which of these intracellular 
      pathway(s) plays a role in the regulation of ethanol consumption by BDNF. We 
      found that inhibition of the MAPK, but not PLC-gamma or PI3K, activity blocks the 
      BDNF-mediated reduction of ethanol consumption. As activation of the MAPK pathway 
      leads to the initiation of transcription and/or translation events, we tested 
      whether the BDNF-mediated reduction of ethanol self-administration requires de 
      novo protein synthesis. We found that the inhibitory effect of BDNF on ethanol 
      intake is blocked by the protein synthesis inhibitor cycloheximide. Together, our 
      results show that BDNF attenuates ethanol drinking via activation of the MAPK 
      pathway in a protein synthesis-dependent manner within the DLS.
CI  - (c) 2012 Federation of European Neuroscience Societies and Blackwell Publishing 
      Ltd.
FAU - Jeanblanc, Jerome
AU  - Jeanblanc J
AD  - Gallo Research Center, University of California, San Francisco, Emeryville, CA, 
      94608, USA.
FAU - Logrip, Marian L
AU  - Logrip ML
FAU - Janak, Patricia H
AU  - Janak PH
FAU - Ron, Dorit
AU  - Ron D
LA  - eng
GR  - R01 AA016848/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121128
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Depressants)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Alcohol Drinking/*metabolism
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Central Nervous System Depressants/pharmacology
MH  - Conditioning, Operant
MH  - Ethanol/pharmacology
MH  - MAP Kinase Signaling System/*physiology
MH  - Male
MH  - Mediodorsal Thalamic Nucleus/drug effects/*metabolism
MH  - Rats
MH  - Rats, Long-Evans
PMC - PMC3577946
MID - NIHMS437026
EDAT- 2012/11/30 06:00
MHDA- 2013/11/05 06:00
PMCR- 2014/02/01
CRDT- 2012/11/30 06:00
PHST- 2012/09/27 00:00 [received]
PHST- 2012/10/19 00:00 [revised]
PHST- 2012/10/23 00:00 [accepted]
PHST- 2012/11/30 06:00 [entrez]
PHST- 2012/11/30 06:00 [pubmed]
PHST- 2013/11/05 06:00 [medline]
PHST- 2014/02/01 00:00 [pmc-release]
AID - 10.1111/ejn.12067 [doi]
PST - ppublish
SO  - Eur J Neurosci. 2013 Feb;37(4):607-12. doi: 10.1111/ejn.12067. Epub 2012 Nov 28.