PMID- 23190308
OWN - NLM
STAT- MEDLINE
DCOM- 20140121
LR  - 20211021
IS  - 1557-9042 (Electronic)
IS  - 0897-7151 (Print)
IS  - 0897-7151 (Linking)
VI  - 30
IP  - 6
DP  - 2013 Mar 15
TI  - Laser therapy and pain-related behavior after injury of the inferior alveolar 
      nerve: possible involvement of neurotrophins.
PG  - 480-6
LID - 10.1089/neu.2012.2603 [doi]
AB  - Nerve-related complications have been frequently reported in dental procedures, 
      and a very frequent type of occurrence involves the inferior alveolar nerve 
      (IAN). The nerve injury in humans often results in persistent pain accompanied by 
      allodynia and hyperalgesia. In this investigation, we used an experimental IAN 
      injury in rats, which was induced by a Crile hemostatic clamp, to evaluate the 
      effects of laser therapy on nerve repair. We also studied the nociceptive 
      behavior (von Frey hair test) before and after the injury and the behavioral 
      effects of treatment with laser therapy (emitting a wavelength of 904 nm, output 
      power of 70 Wpk, a spot area of  approximately 0.1 cm(2), frequency of 9500 Hz, pulse time 60 ns 
      and an energy density of 6 J/cm(2)). As neurotrophins are essential for the process 
      of nerve regeneration, we used immunoblotting techniques to preliminarily examine 
      the effects of laser therapy on the expression of nerve growth factor (NGF) and 
      brain-derived neurotrophic factor (BDNF). The injured animals treated with laser 
      exhibited an improved nociceptive behavior. In irradiated animals, there was an 
      enhanced expression of NGF (53%) and a decreased BDNF expression (40%) after 
      laser therapy. These results indicate that BDNF plays a locally crucial role in 
      pain-related behavior development after IAN injury, increasing after lesions (in 
      parallel to the installation of pain behavior) and decreasing with laser therapy 
      (in parallel to the improvement of pain behavior). On the other hand, NGF 
      probably contributes to the repair of nerve tissue, in addition to improving the 
      pain-related behavior.
FAU - de Oliveira Martins, Daniel
AU  - de Oliveira Martins D
AD  - Laboratory of Functional Neuroanatomy of Pain, Department of Anatomy, University 
      of Sao Paulo, Sao Paulo, Brazil.
FAU - Martinez dos Santos, Fabio
AU  - Martinez dos Santos F
FAU - Evany de Oliveira, Mara
AU  - Evany de Oliveira M
FAU - de Britto, Luiz R G
AU  - de Britto LR
FAU - Benedito Dias Lemos, Jose
AU  - Benedito Dias Lemos J
FAU - Chacur, Marucia
AU  - Chacur M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130320
PL  - United States
TA  - J Neurotrauma
JT  - Journal of neurotrauma
JID - 8811626
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - Low-Level Light Therapy/*methods
MH  - Male
MH  - Mandibular Nerve/*metabolism
MH  - Nerve Growth Factor/*biosynthesis
MH  - Nerve Growth Factors/biosynthesis
MH  - Pain/*metabolism
MH  - Pain Management/methods
MH  - Rats
MH  - Rats, Wistar
MH  - Trigeminal Nerve Injuries/*metabolism/therapy
PMC - PMC3627421
EDAT- 2012/11/30 06:00
MHDA- 2014/01/22 06:00
PMCR- 2014/03/15
CRDT- 2012/11/30 06:00
PHST- 2012/11/30 06:00 [entrez]
PHST- 2012/11/30 06:00 [pubmed]
PHST- 2014/01/22 06:00 [medline]
PHST- 2014/03/15 00:00 [pmc-release]
AID - 10.1089/neu.2012.2603 [pii]
AID - 10.1089/neu.2012.2603 [doi]
PST - ppublish
SO  - J Neurotrauma. 2013 Mar 15;30(6):480-6. doi: 10.1089/neu.2012.2603. Epub 2013 Mar 
      20.