PMID- 23190614
OWN - NLM
STAT- MEDLINE
DCOM- 20160108
LR  - 20211021
IS  - 1557-1246 (Electronic)
IS  - 1087-0547 (Print)
IS  - 1087-0547 (Linking)
VI  - 19
IP  - 9
DP  - 2015 Sep
TI  - Jitter Reduces Response-Time Variability in ADHD: An Ex-Gaussian Analysis.
PG  - 794-804
LID - 10.1177/1087054712464269 [doi]
AB  - OBJECTIVE: "Jitter" involves randomization of intervals between stimulus events. 
      Compared with controls, individuals with ADHD demonstrate greater intrasubject 
      variability (ISV) performing tasks with fixed interstimulus intervals (ISIs). 
      Because Gaussian curves mask the effect of extremely slow or fast response times 
      (RTs), ex-Gaussian approaches have been applied to study ISV. METHOD: This study 
      applied ex-Gaussian analysis to examine the effects of jitter on RT variability 
      in children with and without ADHD. A total of 75 children, aged 9 to 14 years (44 
      ADHD, 31 controls), completed a go/no-go test with two conditions: fixed ISI and 
      jittered ISI. RESULTS: ADHD children showed greater variability, driven by 
      elevations in exponential (tau), but not normal (sigma) components of the RT 
      distribution. Jitter decreased tau in ADHD to levels not statistically different 
      than controls, reducing lapses in performance characteristic of impaired response 
      control. CONCLUSION: Jitter may provide a nonpharmacologic mechanism to 
      facilitate readiness to respond and reduce lapses from sustained (controlled) 
      performance.
CI  - (c) 2012 SAGE Publications.
FAU - Lee, Ryan W Y
AU  - Lee RW
AD  - Kennedy Krieger Institute, Baltimore, MD, USA.
FAU - Jacobson, Lisa A
AU  - Jacobson LA
AD  - Kennedy Krieger Institute, Baltimore, MD, USA Johns Hopkins University, 
      Baltimore, MD, USA.
FAU - Pritchard, Alison E
AU  - Pritchard AE
AD  - Kennedy Krieger Institute, Baltimore, MD, USA Johns Hopkins University, 
      Baltimore, MD, USA.
FAU - Ryan, Matthew S
AU  - Ryan MS
AD  - Kennedy Krieger Institute, Baltimore, MD, USA.
FAU - Yu, Qilu
AU  - Yu Q
AD  - Johns Hopkins University, Baltimore, MD, USA.
FAU - Denckla, Martha B
AU  - Denckla MB
AD  - Kennedy Krieger Institute, Baltimore, MD, USA Johns Hopkins University, 
      Baltimore, MD, USA.
FAU - Mostofsky, Stewart
AU  - Mostofsky S
AD  - Kennedy Krieger Institute, Baltimore, MD, USA Johns Hopkins University, 
      Baltimore, MD, USA.
FAU - Mahone, E Mark
AU  - Mahone EM
AD  - Kennedy Krieger Institute, Baltimore, MD, USA Johns Hopkins University, 
      Baltimore, MD, USA mahone@kennedykrieger.org.
LA  - eng
GR  - P30 HD 24061/HD/NICHD NIH HHS/United States
GR  - UL1 RR025005/RR/NCRR NIH HHS/United States
GR  - R01 MH078160/MH/NIMH NIH HHS/United States
GR  - P50 HD052121/HD/NICHD NIH HHS/United States
GR  - P50 HD 52121/HD/NICHD NIH HHS/United States
GR  - UL1-RR025005/RR/NCRR NIH HHS/United States
GR  - R01 MH085328/MH/NIMH NIH HHS/United States
GR  - P30 HD024061/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20121127
PL  - United States
TA  - J Atten Disord
JT  - Journal of attention disorders
JID - 9615686
SB  - IM
MH  - Adolescent
MH  - Attention Deficit Disorder with Hyperactivity/physiopathology/*psychology
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - Humans
MH  - Male
MH  - Psychomotor Performance/*physiology
MH  - Reaction Time/*physiology
PMC - PMC3600392
MID - NIHMS426304
OTO - NOTNLM
OT  - ADHD
OT  - attention
OT  - ex-Gaussian
OT  - executive function
OT  - jitter
OT  - response time
OT  - statistics
OT  - variability
EDAT- 2012/11/30 06:00
MHDA- 2016/01/09 06:00
PMCR- 2015/09/01
CRDT- 2012/11/30 06:00
PHST- 2012/11/30 06:00 [entrez]
PHST- 2012/11/30 06:00 [pubmed]
PHST- 2016/01/09 06:00 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - 1087054712464269 [pii]
AID - 10.1177/1087054712464269 [doi]
PST - ppublish
SO  - J Atten Disord. 2015 Sep;19(9):794-804. doi: 10.1177/1087054712464269. Epub 2012 
      Nov 27.