PMID- 23193738
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20121130
IS  - 0125-2208 (Print)
IS  - 0125-2208 (Linking)
VI  - 95
IP  - 10
DP  - 2012 Oct
TI  - Analysis of KIR genes in HLA-identical sibling hematopoietic stem cell 
      transplantation in Thai patients with leukemia.
PG  - 1261-5
AB  - BACKGROUND: Killer cell immunoglobulin-like receptors (KIRs) are members of a 
      group of regulatory molecules found on the natural killer (NK) cells that 
      regulate NK cells function by interacting with the human leukocyte antigen (HLA) 
      class I molecules or ligands. The effects of KIR genes on the outcome of 
      hematopoietic stem cell transplantation (HSCT) are still controversial. 
      OBJECTIVE: To investigate the distribution of KIR genes in HLA-identical sibling 
      and the effect of KIR genes on the outcome of HSCT. MATERIAL AND METHOD: The 
      present study included 74 patients and their HLA-identical sibling donors. KIR 
      genes and HLA ligands typing were determined by polymerase chain 
      reaction-sequence specific primer (PCR-SSP). A retrospective study was carried 
      out to analyze the outcomes of the recipients. RESULTS: There was no effect of 
      KIR gene mismatch and missing ligand on the outcome regarding graft-versus host 
      disease (GVHD), relapse, and overall survival (OS) (p > 0.05). However the 
      presence of donor activating KIR2DS5 was associated with decreased aGVHD (p = 
      0.01). CONCLUSION: Our findings suggest an important role of donor activating KIR 
      in identical sibling HSCT.
FAU - Wongwuttisaroj, Natta
AU  - Wongwuttisaroj N
AD  - Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, 
      Mahidol University, Bangkok, Thailand.
FAU - Vejbaesya, Sasijit
AU  - Vejbaesya S
FAU - Chongkolwatana, Viroje
AU  - Chongkolwatana V
FAU - Issaragrisil, Surapol
AU  - Issaragrisil S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Thailand
TA  - J Med Assoc Thai
JT  - Journal of the Medical Association of Thailand = Chotmaihet thangphaet
JID - 7507216
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cohort Studies
MH  - Female
MH  - Genotype
MH  - Graft vs Host Disease/epidemiology/genetics
MH  - HLA Antigens/*genetics
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Leukemia/*genetics/mortality/*therapy
MH  - Male
MH  - Middle Aged
MH  - Receptors, KIR/*genetics
MH  - Siblings
MH  - Survival Rate
MH  - Thailand
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2012/12/01 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
PST - ppublish
SO  - J Med Assoc Thai. 2012 Oct;95(10):1261-5.