PMID- 23194532
OWN - NLM
STAT- MEDLINE
DCOM- 20130517
LR  - 20220321
IS  - 1873-7072 (Electronic)
IS  - 0308-8146 (Linking)
VI  - 136
IP  - 3-4
DP  - 2013 Feb 15
TI  - The in vivo antioxidant and antifibrotic properties of green tea (Camellia 
      sinensis, Theaceae).
PG  - 1337-44
LID - S0308-8146(12)01467-7 [pii]
LID - 10.1016/j.foodchem.2012.09.063 [doi]
AB  - The in vivo antioxidant and antifibrotic properties of green tea (Camellia 
      sinensis, Theaceae) were investigated with a study of carbon tetrachloride 
      (CCl(4))-induced oxidative stress and hepatic fibrosis in male ICR mice. Oral 
      administration of green tea extract at doses of 125, 625 and 1250 mg/kg for 8 
      weeks significantly reduced (p<0.05) the levels of thiobarbituric acid-reactive 
      substances (TBARS) and protein carbonyls in the liver by at least 28% compared 
      with that was induced by CCl(4) (1 mL/kg) in mice. Moreover, green tea extract 
      administration significantly increased (p<0.05) the activities of catalase, 
      glutathione peroxidase (GSH-Px) and glutathione reductase (GSH-Rd) in the liver. 
      Our study found that oral administration of green tea extract prevented 
      CCl(4)-induced hepatic fibrosis, as evidenced by a decreased hydroxyproline level 
      in the liver and a reduced incidence of hepatic fibrosis by histological 
      observations. These results indicate that green tea exhibits potent protective 
      effects against CCl(4)-induced oxidative stress and hepatic fibrosis in mice by 
      inhibiting oxidative damage and increasing antioxidant enzyme activities.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Tsai, Chia-Fang
AU  - Tsai CF
AD  - Department of Biotechnology, TransWorld University, No. 1221, Zhennan Rd., Douliu 
      City, Yunlin County 640, Taiwan.
FAU - Hsu, Yu-Wen
AU  - Hsu YW
FAU - Ting, Hung-Chih
AU  - Ting HC
FAU - Huang, Chun-Fa
AU  - Huang CF
FAU - Yen, Cheng-Chieh
AU  - Yen CC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120928
PL  - England
TA  - Food Chem
JT  - Food chemistry
JID - 7702639
RN  - 0 (Antioxidants)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Animals
MH  - Antioxidants/*administration & dosage/analysis
MH  - Camellia sinensis/*chemistry
MH  - Humans
MH  - Liver/drug effects/metabolism
MH  - Liver Cirrhosis/*drug therapy/metabolism/prevention & control
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Oxidative Stress/drug effects
MH  - Plant Extracts/*administration & dosage/analysis
EDAT- 2012/12/01 06:00
MHDA- 2013/05/18 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/04/24 00:00 [received]
PHST- 2012/07/18 00:00 [revised]
PHST- 2012/09/13 00:00 [accepted]
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2013/05/18 06:00 [medline]
AID - S0308-8146(12)01467-7 [pii]
AID - 10.1016/j.foodchem.2012.09.063 [doi]
PST - ppublish
SO  - Food Chem. 2013 Feb 15;136(3-4):1337-44. doi: 10.1016/j.foodchem.2012.09.063. 
      Epub 2012 Sep 28.