PMID- 23194667
OWN - NLM
STAT- MEDLINE
DCOM- 20130812
LR  - 20131121
IS  - 1873-2747 (Electronic)
IS  - 0361-9230 (Linking)
VI  - 91
DP  - 2013 Feb
TI  - Brain recruitment of dendritic cells following Li-pilocarpine induced status 
      epilepticus in adult rats.
PG  - 8-13
LID - S0361-9230(12)00245-6 [pii]
LID - 10.1016/j.brainresbull.2012.11.007 [doi]
AB  - Activation of inflammatory and immune pathways may contribute to the development 
      of epilepsy. Dendritic cells (DCs), a heterogeneous group of professional antigen 
      presenting cells, can be detected in the brain under several inflammatory 
      conditions. However, the spatiotemporal distribution and origin of 
      seizure-induced DCs accumulation in the brain have not been explored yet. In the 
      present study, we demonstrate the presence of CD11c-positive DCs in the 
      hippocampus, thalamus and temporal cortex following Li-pilocarpine induced status 
      epilepticus (SE) in rats. Recruitment of DCs occurs as early as 1 day following 
      the induction of SE, reaching peak time at day 3, and still evident until day 5. 
      The recruitment of DCs in the brain following lithium chloride administration was 
      not detected. The observed DCs cannot be double-labeled with Iba-1 (an activated 
      microglia marker) and whole-body radiation prevents seizure-induced DCs 
      accumulation in brain parenchyma. Our data suggest that the recruitment of DCs in 
      the epileptic brain may be derived from peripheral circulation and this 
      population of immune cells may be involved in the immune processes after SE.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Li, Xiao-Wei
AU  - Li XW
AD  - Department of Neurology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, Shaanxi 710032, China.
FAU - Yang, Feng
AU  - Yang F
FAU - Wang, Yan-Gang
AU  - Wang YG
FAU - Wang, Jin-Cun
AU  - Wang JC
FAU - Ma, Lei
AU  - Ma L
FAU - Jiang, Wen
AU  - Jiang W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121127
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (Convulsants)
RN  - 01MI4Q9DI3 (Pilocarpine)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Brain/immunology/*pathology
MH  - Convulsants/toxicity
MH  - Dendritic Cells/immunology/*pathology
MH  - Disease Models, Animal
MH  - Immunohistochemistry
MH  - Male
MH  - Pilocarpine/toxicity
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Status Epilepticus/chemically induced/immunology/*pathology
EDAT- 2012/12/01 06:00
MHDA- 2013/08/13 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/06/12 00:00 [received]
PHST- 2012/09/26 00:00 [revised]
PHST- 2012/11/20 00:00 [accepted]
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2013/08/13 06:00 [medline]
AID - S0361-9230(12)00245-6 [pii]
AID - 10.1016/j.brainresbull.2012.11.007 [doi]
PST - ppublish
SO  - Brain Res Bull. 2013 Feb;91:8-13. doi: 10.1016/j.brainresbull.2012.11.007. Epub 
      2012 Nov 27.