PMID- 23196901
OWN - NLM
STAT- MEDLINE
DCOM- 20130621
LR  - 20211203
IS  - 1347-8648 (Electronic)
IS  - 1347-8613 (Linking)
VI  - 120
IP  - 4
DP  - 2012
TI  - Antidepressant-like effect of Fuzi total alkaloid on ovariectomized mice.
PG  - 280-7
AB  - Recent studies in vivo and vitro have shown that Fuzi polysaccharide has an 
      antidepressant-like effect. Polysaccharide and total alkaloid are the two most 
      important components of Fuzi. However, little is known about the 
      antidepressant-like effect of Fuzi total alkaloid. To investigate the 
      antidepressant-like effect of Fuzi total alkaloid, behavioral studies were 
      performed in the open field test and forced swimming test. Repeated intragastric 
      administration of Fuzi total alkaloid for 7 days (10 mg/kg) to normal mice 
      decreased immobility time compared to the vehicle group. Furthermore, repeated 
      administration of Fuzi total alkaloid (10 or 30 mg/kg) to ovariectomized mice 
      also decreased immobility time in a dose-dependent manner. However, these 
      antidepressant-like behavioral effects were not simply due to locomotor 
      hyperactivity. Further experiments showed that Fuzi total alkaloid enhanced the 
      ratio of phospho-CREB/CREB (cAMP response element-binding) and BDNF 
      (brain-derived neurotrophic factor) protein level in the frontal cortex and 
      hippocampus in ovariectomized mice but not in normal mice. These results indicate 
      that the CREB-BDNF pathway may be involved in the antidepressant-like effect of 
      Fuzi total alkaloid in ovariectomized mice.
FAU - Liu, Lei
AU  - Liu L
AD  - Laboratory of Neuroscience, Physiology, School of Life Sciences, Northeast Normal 
      University, Changchun, China.
FAU - Li, Bingjin
AU  - Li B
FAU - Zhou, Yang
AU  - Zhou Y
FAU - Wang, Liang
AU  - Wang L
FAU - Tang, Fang
AU  - Tang F
FAU - Shao, Dongyuan
AU  - Shao D
FAU - Jiang, Xiulan
AU  - Jiang X
FAU - Zhao, Hui
AU  - Zhao H
FAU - Cui, Ranji
AU  - Cui R
FAU - Li, Yuxin
AU  - Li Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121129
PL  - Japan
TA  - J Pharmacol Sci
JT  - Journal of pharmacological sciences
JID - 101167001
RN  - 0 (Alkaloids)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Creb1 protein, mouse)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Diterpenes)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (fuzi drug herbal)
SB  - IM
MH  - Alkaloids/*pharmacology
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism/physiology
MH  - Cyclic AMP Response Element-Binding Protein/metabolism/physiology
MH  - Diterpenes/*pharmacology
MH  - Drugs, Chinese Herbal
MH  - Female
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Motor Activity/drug effects
MH  - *Ovariectomy
MH  - Up-Regulation/drug effects
EDAT- 2012/12/01 06:00
MHDA- 2013/06/25 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2013/06/25 06:00 [medline]
AID - DN/JST.JSTAGE/jphs/12163FP [pii]
AID - 10.1254/jphs.12163fp [doi]
PST - ppublish
SO  - J Pharmacol Sci. 2012;120(4):280-7. doi: 10.1254/jphs.12163fp. Epub 2012 Nov 29.