PMID- 23197167
OWN - NLM
STAT- MEDLINE
DCOM- 20130726
LR  - 20190606
IS  - 1678-4170 (Electronic)
IS  - 0066-782X (Linking)
VI  - 99
IP  - 6
DP  - 2012 Dec
TI  - Malformations detected by abdominal ultrasound in children with congenital heart 
      disease.
PG  - 1092-9
LID - S0066-782X2012005000111 [pii]
AB  - BACKGROUND: Extracardiac malformations may be present in patients with congenital 
      heart disease (CHD), bringing greater risk of comorbidity and mortality. 
      OBJECTIVE: Verify frequency and types of abdominal abnormalities detected in 
      children with and without CHD through abdominal ultrasound (AUS), compare the 
      patients in relation to their dysmorphic/cytogenetic findings and perform an 
      estimative of the cost-effectiveness of the screening through AUS. METHODS: We 
      conducted a cross-sectional study with a control cohort. The cases consisted of 
      patients with CHD admitted for the first time in a pediatric intensive care unit; 
      the controls consisted of children without CHD who underwent AUS at the hospital 
      shortly thereafter a case. All patients with CHD underwent AUS, high-resolution 
      karyotype and fluorescence in situ hybridization (FISH) for microdeletion 
      22q11.2. RESULTS: AUS identified clinically significant abnormalities in 12.2% of 
      the cases and 5.2% of controls (p= 0.009), with a power of significance of 76.6%. 
      Most malformations with clinical significance were renal anomalies (10.4% in 
      cases and 4.9% in controls; p= 0.034). In Brazil, the cost of an AUS examination 
      for the Unified Health System is US$ 21. Since clinically significant 
      abnormalities were observed in one in every 8.2 CHD patients, the cost to 
      identify an affected child was calculated as approximately US$ 176. CONCLUSION: 
      Patients with CHD present a significant frequency of abdominal abnormalities 
      detected by AUS, an inexpensive and noninvasive diagnostic method with good 
      sensitivity. The cost of screening for these defects is considerably lower than 
      the cost to treat the complications of late diagnoses of abdominal malformations 
      such as renal disease.
FAU - Rosa, Rosana Cardoso Manique
AU  - Rosa RC
AD  - Programa de Pos-graduacao em Patologia, Fundacao Universidade Federal de Ciencias 
      da Saude de Porto Alegre, RS, Brasil.
FAU - Rosa, Rafael Fabiano Machado
AU  - Rosa RF
FAU - Flores, Jose Antonio Monteiro
AU  - Flores JA
FAU - Golendziner, Eliete
AU  - Golendziner E
FAU - Oliveira, Ceres Andreia Vieira de
AU  - Oliveira CA
FAU - Varella-Garcia, Marileila
AU  - Varella-Garcia M
FAU - Paskulin, Giorgio Adriano
AU  - Paskulin GA
FAU - Zen, Paulo Ricardo Gazzola
AU  - Zen PR
LA  - eng
LA  - por
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121130
PL  - Brazil
TA  - Arq Bras Cardiol
JT  - Arquivos brasileiros de cardiologia
JID - 0421031
SB  - IM
MH  - Abdomen/*abnormalities/*diagnostic imaging
MH  - Age Distribution
MH  - Brazil
MH  - Child
MH  - Child, Preschool
MH  - Cost-Benefit Analysis
MH  - Epidemiologic Methods
MH  - Female
MH  - Heart Defects, Congenital/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Kidney/abnormalities/diagnostic imaging
MH  - Male
MH  - Sex Distribution
MH  - Ultrasonography
EDAT- 2012/12/01 06:00
MHDA- 2013/07/28 06:00
CRDT- 2012/12/01 06:00
PHST- 2011/10/01 00:00 [received]
PHST- 2012/04/23 00:00 [accepted]
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2013/07/28 06:00 [medline]
AID - S0066-782X2012005000111 [pii]
AID - 10.1590/s0066-782x2012005000111 [doi]
PST - ppublish
SO  - Arq Bras Cardiol. 2012 Dec;99(6):1092-9. doi: 10.1590/s0066-782x2012005000111. 
      Epub 2012 Nov 30.