PMID- 23197471
OWN - NLM
STAT- MEDLINE
DCOM- 20140203
LR  - 20240322
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Print)
IS  - 1053-1807 (Linking)
VI  - 38
IP  - 1
DP  - 2013 Jul
TI  - Towards a five-minute comprehensive cardiac MR examination using highly 
      accelerated parallel imaging with a 32-element coil array: feasibility and 
      initial comparative evaluation.
PG  - 180-8
LID - 10.1002/jmri.23955 [doi]
AB  - PURPOSE: To evaluate the feasibility and perform initial comparative evaluations 
      of a 5-minute comprehensive whole-heart magnetic resonance imaging (MRI) protocol 
      with four image acquisition types: perfusion (PERF), function (CINE), coronary 
      artery imaging (CAI), and late gadolinium enhancement (LGE). MATERIALS AND 
      METHODS: This study protocol was Health Insurance Portability and Accountability 
      Act (HIPAA)-compliant and Institutional Review Board-approved. A 5-minute 
      comprehensive whole-heart MRI examination protocol (Accelerated) using 
      6-8-fold-accelerated volumetric parallel imaging was incorporated into and 
      compared with a standard 2D clinical routine protocol (Standard). Following 
      informed consent, 20 patients were imaged with both protocols. Datasets were 
      reviewed for image quality using a 5-point Likert scale (0 = non-diagnostic, 4 = 
      excellent) in blinded fashion by two readers. RESULTS: Good image quality with 
      full whole-heart coverage was achieved using the accelerated protocol, 
      particularly for CAI, although significant degradations in quality, as compared 
      with traditional lengthy examinations, were observed for the other image types. 
      Mean total scan time was significantly lower for the Accelerated as compared to 
      Standard protocols (28.99 +/- 4.59 min vs. 1.82 +/- 0.05 min, P < 0.05). Overall 
      image quality for the Standard vs. Accelerated protocol was 3.67 +/- 0.29 vs. 1.5 +/- 
      0.51 (P < 0.005) for PERF, 3.48 +/- 0.64 vs. 2.6 +/- 0.68 (P < 0.005) for CINE, 2.35 
      +/- 1.01 vs. 2.48 +/- 0.68 (P = 0.75) for CAI, and 3.67 +/- 0.42 vs. 2.67 +/- 0.84 (P < 
      0.005) for LGE. Diagnostic image quality for Standard vs. Accelerated protocols 
      was 20/20 (100%) vs. 10/20 (50%) for PERF, 20/20 (100%) vs. 18/20 (90%) for CINE, 
      18/20 (90%) vs. 18/20 (90%) for CAI, and 20/20 (100%) vs. 18/20 (90%) for LGE. 
      CONCLUSION: This study demonstrates the technical feasibility and promising image 
      quality of 5-minute comprehensive whole-heart cardiac examinations, with 
      simplified scan prescription and high spatial and temporal resolution enabled by 
      highly parallel imaging technology. The study also highlights technical hurdles 
      that remain to be addressed. Although image quality remained diagnostic for most 
      scan types, the reduced image quality of PERF, CINE, and LGE scans in the 
      Accelerated protocol remain a concern.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Xu, Jian
AU  - Xu J
AD  - Bernard and Irene Schwartz Center for Biomedical Imaging, Department of 
      Radiology, New York University School of Medicine, New York, NY 10016, USA.
FAU - Kim, Daniel
AU  - Kim D
FAU - Otazo, Ricardo
AU  - Otazo R
FAU - Srichai, Monvadi B
AU  - Srichai MB
FAU - Lim, Ruth P
AU  - Lim RP
FAU - Axel, Leon
AU  - Axel L
FAU - Mcgorty, Kelly Anne
AU  - Mcgorty KA
FAU - Niendorf, Thoralf
AU  - Niendorf T
FAU - Sodickson, Daniel K
AU  - Sodickson DK
LA  - eng
GR  - R01 EB000447/EB/NIBIB NIH HHS/United States
GR  - R01-EB000447/EB/NIBIB NIH HHS/United States
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20121129
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Algorithms
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Image Enhancement/instrumentation
MH  - Image Interpretation, Computer-Assisted/*instrumentation
MH  - Imaging, Three-Dimensional/*instrumentation
MH  - Magnetic Resonance Imaging, Cine/*instrumentation
MH  - Magnetics/*instrumentation
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*pathology
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
PMC - PMC3615039
MID - NIHMS415792
OTO - NOTNLM
OT  - breath-hold
OT  - cardiovascular MRI
OT  - parallel imaging
OT  - volumetric
OT  - whole heart
EDAT- 2012/12/01 06:00
MHDA- 2014/02/04 06:00
PMCR- 2014/07/01
CRDT- 2012/12/01 06:00
PHST- 2012/04/26 00:00 [received]
PHST- 2012/10/11 00:00 [accepted]
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2014/02/04 06:00 [medline]
PHST- 2014/07/01 00:00 [pmc-release]
AID - 10.1002/jmri.23955 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2013 Jul;38(1):180-8. doi: 10.1002/jmri.23955. Epub 2012 
      Nov 29.