PMID- 23199771
OWN - NLM
STAT- MEDLINE
DCOM- 20130604
LR  - 20201209
IS  - 0151-9638 (Print)
IS  - 0151-9638 (Linking)
VI  - 139
IP  - 11
DP  - 2012 Nov
TI  - [A case of vitiligo occurring after initiation of antiretroviral treatment and 
      disappearing during this treatment: autoimmune IRIS syndrome?].
PG  - 736-8
LID - S0151-9638(12)00516-9 [pii]
LID - 10.1016/j.annder.2012.06.049 [doi]
AB  - BACKGROUND: Immune reconstitution inflammatory syndrome (IRIS) includes all signs 
      occurring during the reconstitution of an extensive and insufficiently regulated 
      immune response to an infective or a non-infective antigen and observed during 
      the immune suppression phase in an individual. We report a case of vitiligo 
      appearing after the initiation of antiretroviral treatment and with 
      repigmentation during the course of the treatment. PATIENTS AND METHODS: A 
      30-year-old man, seropositive for HIV1-M, consulted for a diffuse eruption of 
      hypopigmented and achromic macules. The lesions appeared 7 weeks after the start 
      of antiretroviral therapy with zidovudine, lamivudine and efavirenz, starting on 
      the forearm and spreading to the remainder of the skin. At control visits during 
      the ensuing two months, gradual repigmentation of the achromic macules was noted. 
      Plasma viral load, determined only during the treatment period, was less than 40 
      copies/ml (1.60(log)). DISCUSSION: This report concerns an original case of 
      vitiligo occurring at the start of antiretroviral treatment in an HIV-positive 
      patient, with spontaneous repigmentation during treatment. The chronology points 
      to a hypothesis of immune reconstitution inflammatory syndrome (IRIS), despite 
      the absence of any indication of the patient's viral load prior to therapy.
CI  - Copyright (c) 2012 Elsevier Masson SAS. All rights reserved.
FAU - Defo, D
AU  - Defo D
AD  - Service de dermatologie, hopital central de Yaounde, BP 12963, Yaounde, Cameroun. 
      defo.defo@ymail.com
FAU - Kouotou, E A
AU  - Kouotou EA
FAU - Bissek, A C
AU  - Bissek AC
FAU - Mboua, J B
AU  - Mboua JB
LA  - fre
PT  - Case Reports
PT  - Journal Article
TT  - Vitiligo regressif au debut d'un traitement antiretroviral : syndrome de 
      reconstitution immunitaire ?
DEP - 20120905
PL  - France
TA  - Ann Dermatol Venereol
JT  - Annales de dermatologie et de venereologie
JID - 7702013
RN  - 0 (Alkynes)
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Benzoxazines)
RN  - 0 (Cyclopropanes)
RN  - 2T8Q726O95 (Lamivudine)
RN  - 4B9XT59T7S (Zidovudine)
RN  - JE6H2O27P8 (efavirenz)
SB  - IM
MH  - Adult
MH  - Alkynes
MH  - Anti-HIV Agents/*adverse effects/therapeutic use
MH  - Benzoxazines/adverse effects/therapeutic use
MH  - Cyclopropanes
MH  - Drug Therapy, Combination
MH  - Follow-Up Studies
MH  - HIV Seropositivity/*drug therapy
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*chemically induced/diagnosis/drug 
      therapy
MH  - Lamivudine/adverse effects/therapeutic use
MH  - Male
MH  - Viral Load
MH  - Vitiligo/*chemically induced/diagnosis/drug therapy
MH  - Zidovudine/adverse effects/therapeutic use
EDAT- 2012/12/04 06:00
MHDA- 2013/06/05 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/03/04 00:00 [received]
PHST- 2012/05/10 00:00 [revised]
PHST- 2012/06/28 00:00 [accepted]
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - S0151-9638(12)00516-9 [pii]
AID - 10.1016/j.annder.2012.06.049 [doi]
PST - ppublish
SO  - Ann Dermatol Venereol. 2012 Nov;139(11):736-8. doi: 10.1016/j.annder.2012.06.049. 
      Epub 2012 Sep 5.