PMID- 23201532
OWN - NLM
STAT- MEDLINE
DCOM- 20130924
LR  - 20211021
IS  - 1096-1208 (Electronic)
IS  - 0882-4010 (Print)
IS  - 0882-4010 (Linking)
VI  - 58
DP  - 2013 May
TI  - Dendritic cells and vaccine design for sexually-transmitted diseases.
PG  - 35-44
LID - S0882-4010(12)00202-1 [pii]
LID - 10.1016/j.micpath.2012.11.010 [doi]
AB  - Dendritic cells (DCs) are major antigen presenting cells (APCs) that can initiate 
      and control host immune responses toward either immunity or tolerance. These 
      features of DCs, as immune orchestrators, are well characterized by their tissue 
      localizations as well as by their subset-dependent functional specialties and 
      plasticity. Thus, the level of protective immunity to invading microbial 
      pathogens can be dependent on the subsets of DCs taking up microbial antigens and 
      their functional plasticity in response to microbial products, host cellular 
      components and the cytokine milieu in the microenvironment. Vaccines are the most 
      efficient and cost-effective preventive medicine against infectious diseases. 
      However, major challenges still remain for the diseases caused by 
      sexually-transmitted pathogens, including HIV, HPV, HSV and Chlamydia. We surmise 
      that the establishment of protective immunity in the female genital mucosa, the 
      major entry and transfer site of these pathogens, will bring significant benefit 
      for the protection against sexually-transmitted diseases. Recent progresses made 
      in DC biology suggest that vaccines designed to target proper DC subsets may 
      permit us to establish protective immunity in the female genital mucosa against 
      sexually-transmitted pathogens.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Duluc, Dorothee
AU  - Duluc D
AD  - Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA.
FAU - Gannevat, Julien
AU  - Gannevat J
FAU - Joo, Hyemee
AU  - Joo H
FAU - Ni, Ling
AU  - Ni L
FAU - Upchurch, Katherine
AU  - Upchurch K
FAU - Boreham, Muriel
AU  - Boreham M
FAU - Carley, Michael
AU  - Carley M
FAU - Stecher, Jack
AU  - Stecher J
FAU - Zurawski, Gerard
AU  - Zurawski G
FAU - Oh, Sangkon
AU  - Oh S
LA  - eng
GR  - 1RC1AI087379-01/AI/NIAID NIH HHS/United States
GR  - U19 AI057234/AI/NIAID NIH HHS/United States
GR  - 1RC2A148460-01/RC/CCR NIH HHS/United States
GR  - RC2 CA148460/CA/NCI NIH HHS/United States
GR  - RC1 AI087379/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121129
PL  - England
TA  - Microb Pathog
JT  - Microbial pathogenesis
JID - 8606191
RN  - 0 (Bacterial Vaccines)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Bacterial Vaccines/genetics/*immunology
MH  - Dendritic Cells/*immunology
MH  - Drug Discovery/trends
MH  - Female
MH  - Genitalia, Female/*immunology
MH  - Humans
MH  - *Immunity, Mucosal
MH  - Sexually Transmitted Diseases/*immunology/*prevention & control
MH  - Viral Vaccines/genetics/*immunology
PMC - PMC3596496
MID - NIHMS425985
COIS- The authors have no conflicting interest
EDAT- 2012/12/04 06:00
MHDA- 2013/09/26 06:00
PMCR- 2014/05/01
CRDT- 2012/12/04 06:00
PHST- 2012/10/15 00:00 [received]
PHST- 2012/11/21 00:00 [revised]
PHST- 2012/11/22 00:00 [accepted]
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2013/09/26 06:00 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - S0882-4010(12)00202-1 [pii]
AID - 10.1016/j.micpath.2012.11.010 [doi]
PST - ppublish
SO  - Microb Pathog. 2013 May;58:35-44. doi: 10.1016/j.micpath.2012.11.010. Epub 2012 
      Nov 29.