PMID- 23202502
OWN - NLM
STAT- MEDLINE
DCOM- 20130516
LR  - 20211021
IS  - 1999-4915 (Electronic)
IS  - 1999-4915 (Linking)
VI  - 4
IP  - 11
DP  - 2012 Nov 1
TI  - Dendritic cell apoptosis and the pathogenesis of dengue.
PG  - 2736-53
LID - 10.3390/v4112736 [doi]
AB  - Dengue viruses and other members of the Flaviviridae family are emerging human 
      pathogens. Dengue is transmitted to humans by Aedes aegypti female mosquitoes. 
      Following infection through the bite, cells of the hematopoietic lineage, like 
      dendritic cells, are the first targets of dengue virus infection. Dendritic cells 
      (DCs) are key antigen presenting cells, sensing pathogens, processing and 
      presenting the antigens to T lymphocytes, and triggering an adaptive immune 
      response. Infection of DCs by dengue virus may induce apoptosis, impairing their 
      ability to present antigens to T cells, and thereby contributing to dengue 
      pathogenesis. This review focuses on general mechanisms by which dengue virus 
      triggers apoptosis, and possible influence of DC-apoptosis on dengue disease 
      severity.
FAU - Martins, Sharon de T
AU  - Martins Sde T
AD  - Laboratory of Molecular Virology of the Carlos Chagas Institute, ICC/Fiocruz, 
      Prof. Algacyr Munhoz Mader Street 3775, CIC, Curitiba, Parana, 81350-010, Brazil. 
      sth_martins@yahoo.com.br
FAU - Silveira, Guilherme F
AU  - Silveira GF
FAU - Alves, Lysangela R
AU  - Alves LR
FAU - Duarte dos Santos, Claudia Nunes
AU  - Duarte dos Santos CN
FAU - Bordignon, Juliano
AU  - Bordignon J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121101
PL  - Switzerland
TA  - Viruses
JT  - Viruses
JID - 101509722
SB  - IM
MH  - Apoptosis/*immunology
MH  - Dendritic Cells/*immunology/metabolism/virology
MH  - Dengue/*immunology/*virology
MH  - Dengue Virus/*physiology
MH  - Host-Pathogen Interactions/immunology
MH  - Humans
PMC - PMC3509670
EDAT- 2012/12/04 06:00
MHDA- 2013/05/17 06:00
PMCR- 2012/11/01
CRDT- 2012/12/04 06:00
PHST- 2012/10/12 00:00 [received]
PHST- 2012/10/30 00:00 [revised]
PHST- 2012/10/31 00:00 [accepted]
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
PHST- 2012/11/01 00:00 [pmc-release]
AID - v4112736 [pii]
AID - viruses-04-02736 [pii]
AID - 10.3390/v4112736 [doi]
PST - epublish
SO  - Viruses. 2012 Nov 1;4(11):2736-53. doi: 10.3390/v4112736.