PMID- 23202828 OWN - NLM STAT- MEDLINE DCOM- 20130205 LR - 20220410 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 9 IP - 11 DP - 2012 Nov 5 TI - Ambient air pollution exposure and respiratory, cardiovascular and cerebrovascular mortality in Cape Town, South Africa: 2001-2006. PG - 3978-4016 LID - 10.3390/ijerph9113978 [doi] AB - Little evidence is available on the strength of the association between ambient air pollution exposure and health effects in developing countries such as South Africa. The association between the 24-h average ambient PM(10), SO(2) and NO(2) levels and daily respiratory (RD), cardiovascular (CVD) and cerebrovascular (CBD) mortality in Cape Town (2001-2006) was investigated with a case-crossover design. For models that included entire year data, an inter-quartile range (IQR) increase in PM(10) (12 mg/m3) and NO(2) (12 mg/m3) significantly increased CBD mortality by 4% and 8%, respectively. A significant increase of 3% in CVD mortality was observed per IQR increase in NO(2) and SO(2) (8 mg/m3). In the warm period, PM(10) was significantly associated with RD and CVD mortality. NO(2) had significant associations with CBD, RD and CVD mortality, whilst SO(2) was associated with CVD mortality. None of the pollutants were associated with any of the three outcomes in the cold period. Susceptible groups depended on the cause-specific mortality and air pollutant. There is significant RD, CVD and CBD mortality risk associated with ambient air pollution exposure in South Africa, higher than reported in developed countries. FAU - Wichmann, Janine AU - Wichmann J AD - School of Health Systems and Public Health, Health Sciences Faculty, University of Pretoria, P.O. Box 667, Pretoria 0001, South Africa. janine.wichmann@up.ac.za FAU - Voyi, Kuku AU - Voyi K LA - eng PT - Journal Article DEP - 20121105 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - *Air Pollution MH - Cardiovascular Diseases/epidemiology/*mortality MH - Case-Control Studies MH - Cerebrovascular Disorders/epidemiology/*mortality MH - Female MH - Humans MH - Male MH - Respiratory Tract Infections/epidemiology/*mortality MH - South Africa/epidemiology PMC - PMC3524609 EDAT- 2012/12/04 06:00 MHDA- 2013/02/06 06:00 PMCR- 2012/11/01 CRDT- 2012/12/04 06:00 PHST- 2012/07/06 00:00 [received] PHST- 2012/10/09 00:00 [revised] PHST- 2012/10/17 00:00 [accepted] PHST- 2012/12/04 06:00 [entrez] PHST- 2012/12/04 06:00 [pubmed] PHST- 2013/02/06 06:00 [medline] PHST- 2012/11/01 00:00 [pmc-release] AID - ijerph9113978 [pii] AID - ijerph-09-03978 [pii] AID - 10.3390/ijerph9113978 [doi] PST - epublish SO - Int J Environ Res Public Health. 2012 Nov 5;9(11):3978-4016. doi: 10.3390/ijerph9113978.