PMID- 23203005
OWN - NLM
STAT- MEDLINE
DCOM- 20140331
LR  - 20221207
IS  - 1559-0100 (Electronic)
IS  - 1355-008X (Linking)
VI  - 44
IP  - 1
DP  - 2013 Aug
TI  - Evaluation of variant A45T in NEUROD1/BETA2 for its association with type 2 
      diabetes mellitus.
PG  - 99-106
LID - 10.1007/s12020-012-9844-3 [doi]
AB  - Heterozygous loss-of-function mutations in NEUROD1 have been identified as a very 
      rare cause of maturity-onset diabetes of the young and neonatal diabetes. 
      Previous studies showed that a common A45T variant located in NEUROD1 was 
      inconsistently associated with type 2 diabetes mellitus (T2DM) in different 
      ethnic populations. This study aimed to evaluate the contribution of variant A45T 
      in the genetic pathogenesis of T2DM. A case-control study in a Chinese Han 
      population was conducted, which included 3,554 (1,155 males/2,399 females) 
      patients with T2DM and 4,181 (1,798 males/2,383 females) control subjects from 13 
      different regions of China. The A45T variant was genotyped by the Illumina 
      GoldenGate platform. A meta-analysis was used to estimate the effects of variant 
      A45T in populations from different ethnic backgrounds. No association in Chinese 
      Han subjects was confirmed in our case control study. A relationship between 
      variant A45T and postprandial glucose was observed in the control group (beta = 
      0.05, p = 0.002). Meta-analyses did not find an association of this polymorphism 
      with T2DM in Chinese, Japanese, and East Asian descent, but did for European 
      descent Caucasians (odds ratio = 1.15, 95 %CI 1.03-1.28, p = 0.01). Our study 
      suggests the variant A45T does not play a major role in the development of T2DM 
      in East Asian descent, and the role in European descent Caucasian needs to be 
      confirmed.
FAU - Han, Xueyao
AU  - Han X
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Peking University Diabetes Center, Beijing, 100044, China.
FAU - Xiao, Jianzhong
AU  - Xiao J
FAU - Ren, Qian
AU  - Ren Q
FAU - Tang, Yong
AU  - Tang Y
FAU - Yang, Wenying
AU  - Yang W
FAU - Ji, Linong
AU  - Ji L
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20121201
PL  - United States
TA  - Endocrine
JT  - Endocrine
JID - 9434444
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (NEUROD1 protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People/genetics
MH  - Basic Helix-Loop-Helix Transcription Factors/*genetics
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Diabetes Mellitus, Type 2/epidemiology/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide/physiology
MH  - White People/genetics
EDAT- 2012/12/04 06:00
MHDA- 2014/04/01 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/09/02 00:00 [received]
PHST- 2012/11/19 00:00 [accepted]
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2014/04/01 06:00 [medline]
AID - 10.1007/s12020-012-9844-3 [doi]
PST - ppublish
SO  - Endocrine. 2013 Aug;44(1):99-106. doi: 10.1007/s12020-012-9844-3. Epub 2012 Dec 
      1.