PMID- 23203037
OWN - NLM
STAT- MEDLINE
DCOM- 20150423
LR  - 20211203
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 13
IP  - 11
DP  - 2012 Oct 26
TI  - Oxidant stress and signal transduction in the nervous system with the PI 3-K, 
      Akt, and mTOR cascade.
PG  - 13830-66
LID - 10.3390/ijms131113830 [doi]
AB  - Oxidative stress impacts multiple systems of the body and can lead to some of the 
      most devastating consequences in the nervous system especially during aging. Both 
      acute and chronic neurodegenerative disorders such as diabetes mellitus, cerebral 
      ischemia, trauma, Alzheimer's disease, Parkinson's disease, Huntington's disease, 
      and tuberous sclerosis through programmed cell death pathways of apoptosis and 
      autophagy can be the result of oxidant stress. Novel therapeutic avenues that 
      focus upon the phosphoinositide 3-kinase (PI 3-K), Akt (protein kinase B), and 
      the mammalian target of rapamycin (mTOR) cascade and related pathways offer 
      exciting prospects to address the onset and potential reversal of 
      neurodegenerative disorders. Effective clinical translation of these pathways 
      into robust therapeutic strategies requires intimate knowledge of the complexity 
      of these pathways and the ability of this cascade to influence biological outcome 
      that can vary among disorders of the nervous system.
FAU - Maiese, Kenneth
AU  - Maiese K
AD  - Laboratory of Cellular and Molecular Signaling, Newark, NJ 07101, USA. 
      wntin75@yahoo.com.
FAU - Chong, Zhao Zhong
AU  - Chong ZZ
FAU - Wang, Shaohui
AU  - Wang S
FAU - Shang, Yan Chen
AU  - Shang YC
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121026
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Cell Death
MH  - Cell Survival
MH  - Diabetes Complications
MH  - Humans
MH  - Nervous System/*metabolism
MH  - Neurodegenerative Diseases/etiology/metabolism
MH  - *Oxidative Stress
MH  - Phosphatidylinositol 3-Kinases/*metabolism
MH  - Proto-Oncogene Proteins c-akt/*metabolism
MH  - *Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
PMC - PMC3509553
EDAT- 2012/12/04 06:00
MHDA- 2012/12/04 06:01
PMCR- 2012/01/01
CRDT- 2012/12/04 06:00
PHST- 2012/10/08 00:00 [received]
PHST- 2012/10/19 00:00 [revised]
PHST- 2012/10/19 00:00 [accepted]
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2012/12/04 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - ijms131113830 [pii]
AID - ijms-13-13830 [pii]
AID - 10.3390/ijms131113830 [doi]
PST - epublish
SO  - Int J Mol Sci. 2012 Oct 26;13(11):13830-66. doi: 10.3390/ijms131113830.