PMID- 23203114
OWN - NLM
STAT- MEDLINE
DCOM- 20150423
LR  - 20211021
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 13
IP  - 11
DP  - 2012 Nov 16
TI  - Mast cells in the pathogenesis of multiple sclerosis and experimental autoimmune 
      encephalomyelitis.
PG  - 15107-25
LID - 10.3390/ijms131115107 [doi]
AB  - Mast cells (MCs) are best known as key immune players in immunoglobulin E 
      (IgE)-dependent allergic reactions. In recent years, several lines of evidence 
      have suggested that MCs might play an important role in several pathological 
      conditions, including autoimmune disorders such as multiple sclerosis (MS) and 
      experimental autoimmune encephalomyelitis (EAE), an animal model for MS. Since 
      their first description in MS plaques in the late 1800s, much effort has been put 
      into elucidating the contribution of MCs to the development of central nervous 
      system (CNS) autoimmunity. Mouse models of MC-deficiency have provided a valuable 
      experimental tool for dissecting MC involvement in MS and EAE. However, to date 
      there is still major controversy concerning the function of MCs in these 
      diseases. Indeed, although MCs have been classically proposed as having a 
      detrimental and pro-inflammatory role, recent literature has questioned and 
      resized the contribution of MCs to the pathology of MS and EAE. In this review, 
      we will present the main evidence obtained in MS and EAE on this topic, and 
      discuss the critical and controversial aspects of such evidence.
FAU - Costanza, Massimo
AU  - Costanza M
AD  - Neuroimmunology and Neuromuscular Disorder Unit, Neurological Institute 
      Foundation IRCCS C. Besta, via Amadeo 42, Milan 20133, Italy. 
      r.pedotti@istituto-besta.it.
FAU - Colombo, Mario P
AU  - Colombo MP
FAU - Pedotti, Rosetta
AU  - Pedotti R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121116
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - Animals
MH  - Autoimmunity
MH  - Central Nervous System/immunology/metabolism
MH  - Disease Models, Animal
MH  - Encephalomyelitis, Autoimmune, Experimental/drug therapy/*etiology/pathology
MH  - Humans
MH  - Mast Cells/cytology/drug effects/*immunology/*metabolism
MH  - Mice
MH  - Multiple Sclerosis/drug therapy/*etiology/pathology
PMC - PMC3509630
EDAT- 2012/12/04 06:00
MHDA- 2012/12/04 06:01
PMCR- 2012/01/01
CRDT- 2012/12/04 06:00
PHST- 2012/08/28 00:00 [received]
PHST- 2012/10/24 00:00 [revised]
PHST- 2012/11/06 00:00 [accepted]
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2012/12/04 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - ijms131115107 [pii]
AID - ijms-13-15107 [pii]
AID - 10.3390/ijms131115107 [doi]
PST - epublish
SO  - Int J Mol Sci. 2012 Nov 16;13(11):15107-25. doi: 10.3390/ijms131115107.