PMID- 23203841
OWN - NLM
STAT- MEDLINE
DCOM- 20131209
LR  - 20130516
IS  - 1559-0283 (Electronic)
IS  - 1085-9195 (Linking)
VI  - 66
IP  - 2
DP  - 2013 Jun
TI  - Dynamic changes of cerebral-specific proteins in full-term newborns with 
      hypoxic-ischemic encephalopathy.
PG  - 389-96
LID - 10.1007/s12013-012-9478-3 [doi]
AB  - The aim of this study was to observe the dynamic changes of serum brain-derived 
      neurotrophic factor (BDNF), S-100B, and Tau proteins levels in full-term newborns 
      with hypoxic-ischemic encephalopathy (HIE) and to discuss their significance in 
      brain damage. Serum samples of 28 full-term newborns diagnosed with HIE and 20 
      controls were obtained in the first 24 h of life. Another serum samples were also 
      taken, respectively, at 3 and 7 days of life in HIE group. The concentrations of 
      BDNF, S-100B, and Tau proteins were measured by the enzyme-linked immunosorbent 
      assay method. Mean concentrations of BDNF, S-100B, and Tau proteins among 
      different time period and in different grades of HIE group were calculated and 
      compared. Compared with the control group, serum BDNF and proteins S-100B levels 
      in HIE group were significantly elevated in 24 h after birth (P < 0.05) and their 
      concentrations were also significantly higher among patients with mod-severe HIE 
      compared to those with mild HIE at 24 h and 7 days after asphyxia (P < 0.05). 
      Regardless of whether mod-severe HIE or mild HIE, there were no significant 
      difference of serum BDNF and proteins S-100B among the three different time 
      periods. There was no difference in Tau protein levels between HIE group and 
      control group, also no difference between mod-severe HIE group and mild HIE 
      group. BDNF and proteins S-100B are up-regulated early in asphyxia neonates with 
      HIE; and the released amount of BDNF and proteins S-100B from nerve center system 
      correlate with the extent of encephalopathy.
FAU - Liu, Fang
AU  - Liu F
AD  - Department of Pediatrics, NICU, Bethune International Peace Hospital, 
      Shijiazhuang Hebei, 050082, China. liufanglafy@yahoo.com.cn
FAU - Yang, Suyan
AU  - Yang S
FAU - Du, Zhifang
AU  - Du Z
FAU - Guo, Zhimei
AU  - Guo Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Biochem Biophys
JT  - Cell biochemistry and biophysics
JID - 9701934
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (S100 Calcium Binding Protein beta Subunit)
RN  - 0 (tau Proteins)
SB  - IM
MH  - Apgar Score
MH  - Asphyxia Neonatorum/diagnosis
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Hypoxia-Ischemia, Brain/*blood/diagnosis
MH  - Infant, Newborn
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - S100 Calcium Binding Protein beta Subunit/*blood
MH  - Term Birth
MH  - Time Factors
MH  - Tomography, X-Ray Computed
MH  - tau Proteins/*blood
EDAT- 2012/12/04 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s12013-012-9478-3 [doi]
PST - ppublish
SO  - Cell Biochem Biophys. 2013 Jun;66(2):389-96. doi: 10.1007/s12013-012-9478-3.