PMID- 23203888
OWN - NLM
STAT- MEDLINE
DCOM- 20130513
LR  - 20240505
IS  - 1362-4962 (Electronic)
IS  - 0305-1048 (Print)
IS  - 0305-1048 (Linking)
VI  - 41
IP  - Database issue
DP  - 2013 Jan
TI  - Interferome v2.0: an updated database of annotated interferon-regulated genes.
PG  - D1040-6
LID - 10.1093/nar/gks1215 [doi]
AB  - Interferome v2.0 (http://interferome.its.monash.edu.au/interferome/) is an update 
      of an earlier version of the Interferome DB published in the 2009 NAR database 
      edition. Vastly improved computational infrastructure now enables more complex 
      and faster queries, and supports more data sets from types I, II and III 
      interferon (IFN)-treated cells, mice or humans. Quantitative, MIAME compliant 
      data are collected, subjected to thorough, standardized, quantitative and 
      statistical analyses and then significant changes in gene expression are 
      uploaded. Comprehensive manual collection of metadata in v2.0 allows flexible, 
      detailed search capacity including the parameters: range of -fold change, IFN 
      type, concentration and time, and cell/tissue type. There is no limit to the 
      number of genes that can be used to search the database in a single query. 
      Secondary analysis such as gene ontology, regulatory factors, chromosomal 
      location or tissue expression plots of IFN-regulated genes (IRGs) can be 
      performed in Interferome v2.0, or data can be downloaded in convenient text 
      formats compatible with common secondary analysis programs. Given the importance 
      of IFN to innate immune responses in infectious, inflammatory diseases and 
      cancer, this upgrade of the Interferome to version 2.0 will facilitate the 
      identification of gene signatures of importance in the pathogenesis of these 
      diseases.
FAU - Rusinova, Irina
AU  - Rusinova I
AD  - Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical 
      Research, Monash University, Clayton, Victoria, Australia.
FAU - Forster, Sam
AU  - Forster S
FAU - Yu, Simon
AU  - Yu S
FAU - Kannan, Anitha
AU  - Kannan A
FAU - Masse, Marion
AU  - Masse M
FAU - Cumming, Helen
AU  - Cumming H
FAU - Chapman, Ross
AU  - Chapman R
FAU - Hertzog, Paul J
AU  - Hertzog PJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121129
PL  - England
TA  - Nucleic Acids Res
JT  - Nucleic acids research
JID - 0411011
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - Animals
MH  - *Databases, Genetic
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Interferons/*pharmacology
MH  - Internet
MH  - Mice
MH  - Molecular Sequence Annotation
MH  - Transcriptome
PMC - PMC3531205
EDAT- 2012/12/04 06:00
MHDA- 2013/05/15 06:00
PMCR- 2012/11/29
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2013/05/15 06:00 [medline]
PHST- 2012/11/29 00:00 [pmc-release]
AID - gks1215 [pii]
AID - 10.1093/nar/gks1215 [doi]
PST - ppublish
SO  - Nucleic Acids Res. 2013 Jan;41(Database issue):D1040-6. doi: 10.1093/nar/gks1215. 
      Epub 2012 Nov 29.