PMID- 23204834
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121204
LR  - 20211021
IS  - 1177-5483 (Electronic)
IS  - 1177-5467 (Print)
IS  - 1177-5467 (Linking)
VI  - 6
DP  - 2012
TI  - Optimizing visualization in enhanced depth imaging OCT in healthy subjects and 
      patients with retinal pigment epithelial detachment.
PG  - 1915-20
LID - 10.2147/OPTH.S35596 [doi]
AB  - BACKGROUND: This study's objective was to optimize the visualization of three 
      different spectral-domain optical coherence tomography (SD-OCT) display 
      modalities and evaluate enhanced depth imaging (EDI) by comparing the maximum 
      depth of assessment in conventional versus inverted cross-sectional OCT images in 
      healthy subjects and in patients with retinal pigment epithelial detachment 
      (PED). METHODS: Cross-sectional SD-OCT conventional and inverted images were 
      obtained with the HRA2 (Heidelberg Retina Angiograph II, Heidelberg Engineering, 
      Heidelberg, Germany). Horizontal as well as vertical sections in three different 
      display modes were blinded for evaluation by three independent, experienced 
      graders for maximal imaging depth of the deep ocular fundus layers. RESULTS: The 
      mean imaging depth as measured from the inner segment/outer segment (IS/OS) to 
      the outer choroid of all 14 healthy subjects was 197 +/- 44 mum vs 263 +/- 56 mum for 
      conventional vs EDI scans: in black/white mode, it was significantly lower (P < 
      0.001) than in white/black mode (249 +/- 42 mum vs 337 +/- 71 mum) and color/heat mode 
      (254 +/- 48 mum vs 354 +/- 73 mum). The mean imaging depth of all 14 study eyes with 
      PED was 240 +/- 78 mum vs 345 +/- 100 mum for conventional vs EDI scans in black/white 
      mode, and was significantly lower (P < 0.001) than in white/black mode (393 +/- 104 
      mum vs 464 +/- 126 mum) and in color/heat mode (373 +/- 106 mum vs 453 +/- 114 mum). In 
      each display modality of healthy subjects and of patients with PED, EDI scans 
      showed a significantly higher imaging depth than the corresponding conventional 
      scans. CONCLUSION: White/black and color/heat modes allow increased imaging 
      depth, compared to black/white mode using both conventional or EDI OCT scans in 
      healthy subjects or patients with PED. EDI obtained with HRA2 significantly 
      improves the imaging depth, compared to conventional OCT scans.
FAU - Reznicek, Lukas
AU  - Reznicek L
AD  - Department of Ophthalmology, Ludwig Maximilians University Muenchen, Munich, 
      Germany.
FAU - Vounotrypidis, Efstathios
AU  - Vounotrypidis E
FAU - Seidensticker, Florian
AU  - Seidensticker F
FAU - Kortuem, Karsten
AU  - Kortuem K
FAU - Kampik, Anselm
AU  - Kampik A
FAU - Neubauer, Aljoscha S
AU  - Neubauer AS
FAU - Wolf, Armin
AU  - Wolf A
LA  - eng
PT  - Case Reports
DEP - 20121121
PL  - New Zealand
TA  - Clin Ophthalmol
JT  - Clinical ophthalmology (Auckland, N.Z.)
JID - 101321512
PMC - PMC3508745
OTO - NOTNLM
OT  - EDI OCT
OT  - OCT
OT  - enhanced depth imaging
OT  - imaging mode
OT  - optical coherence tomography
OT  - pigment epithelial detachment
EDAT- 2012/12/04 06:00
MHDA- 2012/12/04 06:01
PMCR- 2012/11/21
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2012/12/04 06:01 [medline]
PHST- 2012/11/21 00:00 [pmc-release]
AID - opth-6-1915 [pii]
AID - 10.2147/OPTH.S35596 [doi]
PST - ppublish
SO  - Clin Ophthalmol. 2012;6:1915-20. doi: 10.2147/OPTH.S35596. Epub 2012 Nov 21.