PMID- 23206930
OWN - NLM
STAT- MEDLINE
DCOM- 20130819
LR  - 20220309
IS  - 1873-7862 (Electronic)
IS  - 0924-977X (Print)
IS  - 0924-977X (Linking)
VI  - 23
IP  - 1
DP  - 2013 Jan
TI  - Reward circuit connectivity relates to delay discounting in children with 
      attention-deficit/hyperactivity disorder.
PG  - 33-45
LID - S0924-977X(12)00306-9 [pii]
LID - 10.1016/j.euroneuro.2012.10.015 [doi]
AB  - Attention-deficit/hyperactivity disorder (ADHD) is a prevalent psychiatric 
      disorder that has poor long-term outcomes and remains a major public health 
      concern. Recent theories have proposed that ADHD arises from alterations in 
      multiple neural pathways. Alterations in reward circuits are hypothesized as one 
      core dysfunction, leading to altered processing of anticipated rewards. The 
      nucleus accumbens (NAcc) is particularly important for reward processes; 
      task-based fMRI studies have found atypical activation of this region while the 
      participants performed a reward task. Understanding how reward circuits are 
      involved with ADHD may be further enhanced by considering how the NAcc interacts 
      with other brain regions. Here we used the technique of resting-state functional 
      connectivity MRI (rs-fcMRI) to examine the alterations in the NAcc interactions 
      and how they relate to impulsive decision making in ADHD. Using rs-fcMRI, this 
      study: examined differences in functional connectivity of the NAcc between 
      children with ADHD and control children; correlated the functional connectivity 
      of NAcc with impulsivity, as measured by a delay discounting task; and combined 
      these two initial segments to identify the atypical NAcc connections that were 
      associated with impulsive decision making in ADHD. We found that functional 
      connectivity of NAcc was atypical in children with ADHD and the ADHD-related 
      increased connectivity between NAcc and the prefrontal cortex was associated with 
      greater impulsivity (steeper delayed-reward discounting). These findings are 
      consistent with the hypothesis that atypical signaling of the NAcc to the 
      prefrontal cortex in ADHD may lead to excessive approach and failure in 
      estimating future consequences; thus, leading to impulsive behavior.
CI  - Copyright (c) 2012 Elsevier B.V. and ECNP. All rights reserved.
FAU - Costa Dias, Taciana G
AU  - Costa Dias TG
AD  - Department of Behavioral Neuroscience, Oregon Health & Science University, 
      Portland, OR, USA. tacigcdias@yahoo.com.br
FAU - Wilson, Vanessa B
AU  - Wilson VB
FAU - Bathula, Deepti R
AU  - Bathula DR
FAU - Iyer, Swathi P
AU  - Iyer SP
FAU - Mills, Kathryn L
AU  - Mills KL
FAU - Thurlow, Bria L
AU  - Thurlow BL
FAU - Stevens, Corinne A
AU  - Stevens CA
FAU - Musser, Erica D
AU  - Musser ED
FAU - Carpenter, Samuel D
AU  - Carpenter SD
FAU - Grayson, David S
AU  - Grayson DS
FAU - Mitchell, Suzanne H
AU  - Mitchell SH
FAU - Nigg, Joel T
AU  - Nigg JT
FAU - Fair, Damien A
AU  - Fair DA
LA  - eng
GR  - UL1RR024140/RR/NCRR NIH HHS/United States
GR  - K99/R00MH091238/MH/NIMH NIH HHS/United States
GR  - R01 MH096773/MH/NIMH NIH HHS/United States
GR  - R00 MH091238/MH/NIMH NIH HHS/United States
GR  - R01MH096773/MH/NIMH NIH HHS/United States
GR  - UL1 RR024140/RR/NCRR NIH HHS/United States
GR  - K99 MH091238/MH/NIMH NIH HHS/United States
GR  - R01 MH086654/MH/NIMH NIH HHS/United States
GR  - R01MH086654/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121201
PL  - Netherlands
TA  - Eur Neuropsychopharmacol
JT  - European neuropsychopharmacology : the journal of the European College of 
      Neuropsychopharmacology
JID - 9111390
SB  - IM
MH  - Attention Deficit Disorder with 
      Hyperactivity/*metabolism/pathology/physiopathology/psychology
MH  - Child
MH  - Child Behavior
MH  - Decision Making
MH  - Female
MH  - Functional Neuroimaging
MH  - Humans
MH  - Impulsive Behavior/etiology/psychology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Nerve Net/*metabolism/pathology
MH  - Neural Pathways
MH  - Nucleus Accumbens/*metabolism/pathology
MH  - Psychiatric Status Rating Scales
MH  - Reward
MH  - *Signal Transduction
MH  - Task Performance and Analysis
MH  - Time Factors
MH  - *Up-Regulation
PMC - PMC3581744
MID - NIHMS420608
EDAT- 2012/12/05 06:00
MHDA- 2013/08/21 06:00
PMCR- 2014/01/01
CRDT- 2012/12/05 06:00
PHST- 2012/05/14 00:00 [received]
PHST- 2012/10/17 00:00 [revised]
PHST- 2012/10/29 00:00 [accepted]
PHST- 2012/12/05 06:00 [entrez]
PHST- 2012/12/05 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - S0924-977X(12)00306-9 [pii]
AID - 10.1016/j.euroneuro.2012.10.015 [doi]
PST - ppublish
SO  - Eur Neuropsychopharmacol. 2013 Jan;23(1):33-45. doi: 
      10.1016/j.euroneuro.2012.10.015. Epub 2012 Dec 1.