PMID- 23208316
OWN - NLM
STAT- MEDLINE
DCOM- 20131231
LR  - 20130605
IS  - 1476-5365 (Electronic)
IS  - 0268-3369 (Linking)
VI  - 48
IP  - 6
DP  - 2013 Jun
TI  - Unrelated SCT induces long-term remission in patients with blastic plasmacytoid 
      dendritic cell neoplasm.
PG  - 799-802
LID - 10.1038/bmt.2012.242 [doi]
AB  - Blastic plasmacytoid DC neoplasm (BPDCN) is a rare haematopoietic malignancy with 
      an aggressive behaviour. We evaluated five patients allografted as consolidative 
      treatment with an unrelated donor in first or subsequent remission. Four patients 
      received a reduced intensity-conditioning regimen because of age or 
      co-morbidities. As the stem cell sources, two umbilical cord blood-(UCB), two 
      PBSC- and one BM graft were used. No GVHD was observed in the patients who 
      received a UCB graft. However, both developed a post-transplant-associated 
      lymphoproliferative disease. So far, only one patient has experienced relapse and 
      was consecutively treated by escalated donor lymphocyte infusions (DLI). A potent 
      graft-versus-leukaemia (GVL) effect was induced leading to a 17-month-long CR. 
      Four patients are still in ongoing CR with median disease-free and overall 
      survivals of 17 and 21 months. Thus, allogeneic SCT in BPDCN offers a potential 
      curative option for patients with a compatible donor. UCB is an attractive 
      alternative as a stem cell source. For relapsing patients, DLI can exert a 
      powerful GVL effect.
FAU - Unteregger, M
AU  - Unteregger M
AD  - Department of Internal Medicine, Division of Haematology, Medical University of 
      Graz, Graz, Austria.
FAU - Valentin, A
AU  - Valentin A
FAU - Zinke-Cerwenka, W
AU  - Zinke-Cerwenka W
FAU - Troppan, K
AU  - Troppan K
FAU - Deutsch, A
AU  - Deutsch A
FAU - Cerroni, L
AU  - Cerroni L
FAU - Linkesch, W
AU  - Linkesch W
FAU - Neumeister, P
AU  - Neumeister P
LA  - eng
PT  - Journal Article
DEP - 20121203
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
SB  - IM
MH  - Adult
MH  - Disease-Free Survival
MH  - Female
MH  - Follow-Up Studies
MH  - *Graft vs Leukemia Effect
MH  - Humans
MH  - Lymphoproliferative Disorders/etiology/mortality/*therapy
MH  - Male
MH  - Middle Aged
MH  - Neoplasms, Plasma Cell/mortality/*therapy
MH  - *Stem Cell Transplantation
MH  - Survival Rate
MH  - Time Factors
MH  - *Transplantation Conditioning
MH  - Unrelated Donors
EDAT- 2012/12/05 06:00
MHDA- 2014/01/01 06:00
CRDT- 2012/12/05 06:00
PHST- 2012/12/05 06:00 [entrez]
PHST- 2012/12/05 06:00 [pubmed]
PHST- 2014/01/01 06:00 [medline]
AID - bmt2012242 [pii]
AID - 10.1038/bmt.2012.242 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2013 Jun;48(6):799-802. doi: 10.1038/bmt.2012.242. Epub 
      2012 Dec 3.