PMID- 23209335
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121205
LR  - 20211021
IS  - 0044-5991 (Print)
IS  - 1347-5800 (Electronic)
IS  - 0044-5991 (Linking)
VI  - 45
IP  - 5
DP  - 2012 Oct 31
TI  - Role of stress-related brain-derived neurotrophic factor (BDNF) in the rat 
      submandibular gland.
PG  - 261-7
LID - 10.1267/ahc.12017 [doi]
AB  - The nerve growth factor (NGF) family comprises NGF, brain-derived neurotrophic 
      factor (BDNF) and neurotrophins (NTs)-3, -4/5, -6 and -7, all of which are 
      collectively referred to as neurotrophins. However, the expression of 
      neurotrophins other than NGF in the salivary gland has not been described in 
      detail. Through interaction with the TrkB receptor, BDNF plays an important role 
      in long-term potentiation. We found that BDNF expression increased within 
      submandibular gland tissue in response to stress, suggesting that the salivary 
      glands are sensitive to stress. In addition, stress caused increases in plasma 
      BDNF derived from the submandibular gland and in TrkB receptor mRNA in the 
      adrenal medulla. Plasma BDNF might activate TrkB receptors in the adrenal medulla 
      during acute stress. The salivary glands are likely to influence not only oral 
      health, but also systemic organs. This review addressed the relationship between 
      hormone-like effects and stress-related BDNF expression in the rat submandibular 
      gland.
FAU - Tsukinoki, Keiichi
AU  - Tsukinoki K
AD  - Department of Environmental Pathology, Graduate School, Kanagawa Dental College, 
      82, Inaoka, Yokoshika, Kanagawa 238-8580, Japan.
FAU - Saruta, Juri
AU  - Saruta J
LA  - eng
PT  - Journal Article
DEP - 20120922
PL  - Japan
TA  - Acta Histochem Cytochem
JT  - Acta histochemica et cytochemica
JID - 0147110
PMC - PMC3496862
OTO - NOTNLM
OT  - brain-derived neurotrophic factor (BDNF)
OT  - plasma
OT  - salivary gland
OT  - stress
EDAT- 2012/12/05 06:00
MHDA- 2012/12/05 06:01
PMCR- 2012/10/31
CRDT- 2012/12/05 06:00
PHST- 2012/05/02 00:00 [received]
PHST- 2012/08/01 00:00 [accepted]
PHST- 2012/12/05 06:00 [entrez]
PHST- 2012/12/05 06:00 [pubmed]
PHST- 2012/12/05 06:01 [medline]
PHST- 2012/10/31 00:00 [pmc-release]
AID - AHC12017 [pii]
AID - 10.1267/ahc.12017 [doi]
PST - ppublish
SO  - Acta Histochem Cytochem. 2012 Oct 31;45(5):261-7. doi: 10.1267/ahc.12017. Epub 
      2012 Sep 22.