PMID- 2321006
OWN - NLM
STAT- MEDLINE
DCOM- 19900427
LR  - 20210928
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 247
IP  - 4949 Pt 1
DP  - 1990 Mar 23
TI  - Neurotrophin-3: a neurotrophic factor related to NGF and BDNF.
PG  - 1446-51
AB  - The development and maintenance of the nervous system depends on proteins known 
      as neurotrophic factors. Although the prototypical neurotrophic factor, nerve 
      growth factor (NGF), has been intensively studied for decades, the discovery and 
      characterization of additional such factors has been impeded by their low 
      abundance. Sequence homologies between NGF and the recently cloned brain-derived 
      neurotrophic factor (BDNF) were used to design a strategy that has now resulted 
      in the cloning of a gene encoding a novel neurotrophic factor, termed 
      neurotrophin-3 (NT-3). The distribution of NT-3 messenger RNA and its biological 
      activity on a variety of neuronal populations clearly distinguish NT-3 from NGF 
      and BDNF, and provide compelling evidence that NT-3 is an authentic neurotrophic 
      factor that has its own characteristic role in vivo.
FAU - Maisonpierre, P C
AU  - Maisonpierre PC
AD  - Regeneron Pharmaceuticals, Inc., Tarrytown, New York 10591.
FAU - Belluscio, L
AU  - Belluscio L
FAU - Squinto, S
AU  - Squinto S
FAU - Ip, N Y
AU  - Ip NY
FAU - Furth, M E
AU  - Furth ME
FAU - Lindsay, R M
AU  - Lindsay RM
FAU - Yancopoulos, G D
AU  - Yancopoulos GD
LA  - eng
SI  - GENBANK/M33968
PT  - Journal Article
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Brain-Derived Neurotrophic Factor
MH  - Cells, Cultured
MH  - Cloning, Molecular
MH  - DNA/genetics
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nerve Growth Factors/biosynthesis/*genetics/physiology
MH  - Nerve Tissue Proteins/biosynthesis/*genetics/physiology
MH  - Neurons/physiology
MH  - Polymerase Chain Reaction
MH  - Rats
MH  - Restriction Mapping
MH  - Sequence Homology, Nucleic Acid
EDAT- 1990/03/23 00:00
MHDA- 1990/03/23 00:01
CRDT- 1990/03/23 00:00
PHST- 1990/03/23 00:00 [pubmed]
PHST- 1990/03/23 00:01 [medline]
PHST- 1990/03/23 00:00 [entrez]
AID - 10.1126/science.247.4949.1446 [doi]
PST - ppublish
SO  - Science. 1990 Mar 23;247(4949 Pt 1):1446-51. doi: 10.1126/science.247.4949.1446.