PMID- 23211562
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20211021
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 239
DP  - 2013 Jun 3
TI  - Sex and stress hormone influences on the expression and activity of brain-derived 
      neurotrophic factor.
PG  - 295-303
LID - S0306-4522(12)01128-1 [pii]
LID - 10.1016/j.neuroscience.2012.10.073 [doi]
AB  - The neurotrophin, brain-derived neurotrophic factor (BDNF), is recognized as a 
      key component in the regulation of CNS ontogeny, homeostasis and adult 
      neuroplasticity. The importance of BDNF in CNS development and function is well 
      documented by numerous reports from animal studies linking abnormal BDNF 
      signaling to metabolic disturbances and anxiety or depressive-like behavior. 
      Despite the diverse roles for BDNF in nearly all aspects of CNS physiology, the 
      regulation of BDNF expression, as well as our understanding of the signaling 
      mechanisms associated with this neurotrophin, remains incomplete. However, links 
      between sex hormones such as estradiol and testosterone, as well as endogenous 
      and synthetic glucocorticoids (GCs), have emerged as important mediators of BDNF 
      expression and function. Examples of such regulation include brain 
      region-specific induction of Bdnf mRNA in response to estradiol. Additional 
      studies have also documented regulation of the expression of the high-affinity 
      BDNF receptor Tropomyosin-Related Kinase B by estradiol, thus implicating sex 
      steroids not only in the regulation of BDNF expression, but also in mechanisms of 
      signaling associated with it. In addition to gonadal steroids, further evidence 
      also suggests functional interaction between BDNF and GCs, such as in the 
      regulation of corticotrophin-releasing hormone and other important neuropeptides. 
      In this review, we provide an overview of the roles played by selected sex or 
      stress hormones in the regulation of BDNF expression and signaling in the CNS.
CI  - Copyright (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Carbone, D L
AU  - Carbone DL
AD  - University of Arizona College of Medicine-Phoenix, Department of Basic Medical 
      Sciences, Phoenix, AZ 85004-2157, USA. carbone@email.arizona.edu
FAU - Handa, R J
AU  - Handa RJ
LA  - eng
GR  - P50 MH082679/MH/NIMH NIH HHS/United States
GR  - R01 NS039951/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20121202
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glucocorticoids)
RN  - 0 (Gonadal Steroid Hormones)
SB  - IM
MH  - Animals
MH  - Brain/*physiology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Glucocorticoids/*metabolism
MH  - Gonadal Steroid Hormones/*metabolism
MH  - Humans
MH  - Signal Transduction/*physiology
PMC - PMC3609934
MID - NIHMS426618
EDAT- 2012/12/06 06:00
MHDA- 2013/10/18 06:00
PMCR- 2014/06/03
CRDT- 2012/12/06 06:00
PHST- 2012/09/05 00:00 [received]
PHST- 2012/10/30 00:00 [revised]
PHST- 2012/10/31 00:00 [accepted]
PHST- 2012/12/06 06:00 [entrez]
PHST- 2012/12/06 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
PHST- 2014/06/03 00:00 [pmc-release]
AID - S0306-4522(12)01128-1 [pii]
AID - 10.1016/j.neuroscience.2012.10.073 [doi]
PST - ppublish
SO  - Neuroscience. 2013 Jun 3;239:295-303. doi: 10.1016/j.neuroscience.2012.10.073. 
      Epub 2012 Dec 2.