PMID- 23211629
OWN - NLM
STAT- MEDLINE
DCOM- 20130722
LR  - 20211203
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1492
DP  - 2013 Jan 25
TI  - Resveratrol pre-treatment reduces early inflammatory responses induced by status 
      epilepticus via mTOR signaling.
PG  - 122-9
LID - S0006-8993(12)01821-5 [pii]
LID - 10.1016/j.brainres.2012.11.027 [doi]
AB  - Resveratrol is indicated to be involved in neuroprotection and anti-inflammation 
      in epileptic rats. The molecular mechanism is still not fully understood. In this 
      study, we investigated the role of resveratrol in nuclear factor-kappa B 
      associated inflammatory responses induced by status epilepticus. Our data showed 
      that seizures activated mammalian target of rapamycin (mTOR), increased the 
      activity of nuclear factor-kappa B and promoted the expressions of inflammatory 
      molecules including inducible nitric oxide synthase, cyclooxygenase-2 and 
      interleukin-1beta. Futhermore, resveratrol significantly inhibited the activation of 
      nuclear factor-kappa B and the production of proinflammatory molecules via mTOR 
      pathway. Additionally, we also proved that the inhibition of mTOR signal by 
      resveratrol was mostly attributed to AMP-activated kinase (AMPK) activation. 
      Altogether, our results suggest that resveratrol suppresses inflammatory 
      responses induced by seizures partially via AMPK/mTOR pathway.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Wang, Sheng-Jun
AU  - Wang SJ
AD  - Department of Neurology, Qilu Hospital, Shandong University, 107#, Wenhua Xi 
      Road, Ji'nan 250012, PR China.
FAU - Bo, Qi-Yu
AU  - Bo QY
FAU - Zhao, Xiu-He
AU  - Zhao XH
FAU - Yang, Xue
AU  - Yang X
FAU - Chi, Zhao-Fu
AU  - Chi ZF
FAU - Liu, Xue-Wu
AU  - Liu XW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121202
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Stilbenes)
RN  - EC 2.7.1.1 (mTOR protein, rat)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
MH  - Blotting, Western
MH  - Electrophoretic Mobility Shift Assay
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Hippocampus/metabolism
MH  - Inflammation/*etiology/metabolism
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Real-Time Polymerase Chain Reaction
MH  - Resveratrol
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Signal Transduction/drug effects/physiology
MH  - Status Epilepticus/complications/*metabolism
MH  - Stilbenes/*pharmacology
MH  - TOR Serine-Threonine Kinases/*metabolism
EDAT- 2012/12/06 06:00
MHDA- 2013/07/23 06:00
CRDT- 2012/12/06 06:00
PHST- 2012/08/16 00:00 [received]
PHST- 2012/10/04 00:00 [revised]
PHST- 2012/11/17 00:00 [accepted]
PHST- 2012/12/06 06:00 [entrez]
PHST- 2012/12/06 06:00 [pubmed]
PHST- 2013/07/23 06:00 [medline]
AID - S0006-8993(12)01821-5 [pii]
AID - 10.1016/j.brainres.2012.11.027 [doi]
PST - ppublish
SO  - Brain Res. 2013 Jan 25;1492:122-9. doi: 10.1016/j.brainres.2012.11.027. Epub 2012 
      Dec 2.