PMID- 23211707
OWN - NLM
STAT- MEDLINE
DCOM- 20130222
LR  - 20211021
IS  - 1945-7170 (Electronic)
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 154
IP  - 1
DP  - 2013 Jan
TI  - Steroid receptor coactivator-1 mediates estrogenic actions to prevent body weight 
      gain in female mice.
PG  - 150-8
LID - 10.1210/en.2012-2007 [doi]
AB  - Estrogen receptor-alpha (ERalpha) expressed by hypothalamic proopiomelanocortin and 
      steroidogenic factor-1 neurons largely mediates the antiobesity effects of 
      estrogens in females. However, the critical molecular events that are coupled to 
      ERalpha and mediate estrogenic effects on energy balance remain unknown. In the 
      current study, we demonstrated that steroid receptor coactivator-1 (SRC1), a 
      nuclear receptor coactivator, is abundantly expressed by both proopiomelanocortin 
      and steroidogenic factor-1 neurons. We further showed that central administration 
      of an ERalpha agonist, propyl pyrazole triol, acutely increases physical interaction 
      between SRC1 and ERalpha in the hypothalamus. Finally, we demonstrated that the 
      effects of estrogens on energy homeostasis are significantly blunted in female 
      mice lacking SRC1 globally. Collectively our results indicate that SRC1 is 
      functionally required to mediate the antiobesity effects of estrogen-ERalpha signals.
FAU - Zhu, Liangru
AU  - Zhu L
AD  - Children's Nutrition Research Center, Baylor College of Medicine, One Baylor 
      Plaza, Houston, TX 77479, USA.
FAU - Yang, Yongjie
AU  - Yang Y
FAU - Xu, Pingwen
AU  - Xu P
FAU - Zou, Fang
AU  - Zou F
FAU - Yan, Xiaofeng
AU  - Yan X
FAU - Liao, Lan
AU  - Liao L
FAU - Xu, Jianming
AU  - Xu J
FAU - O'Malley, Bert W
AU  - O'Malley BW
FAU - Xu, Yong
AU  - Xu Y
LA  - eng
GR  - R01HD008818/HD/NICHD NIH HHS/United States
GR  - R01DK093587/DK/NIDDK NIH HHS/United States
GR  - P30 DK079638-03/DK/NIDDK NIH HHS/United States
GR  - R00 DK085330/DK/NIDDK NIH HHS/United States
GR  - P01 DK059820/DK/NIDDK NIH HHS/United States
GR  - R01 HD007857/HD/NICHD NIH HHS/United States
GR  - R01 DK093587/DK/NIDDK NIH HHS/United States
GR  - P30 DK079638/DK/NIDDK NIH HHS/United States
GR  - P01DK059820/DK/NIDDK NIH HHS/United States
GR  - R00DK085330/DK/NIDDK NIH HHS/United States
GR  - R01 CA112403/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121204
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogens)
RN  - 0 (Phenols)
RN  - 0 (Pyrazoles)
RN  - 0 (Steroidogenic Factor 1)
RN  - 0 (steroidogenic factor 1, mouse)
RN  - 0T83Y6JZPF (4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol)
RN  - 66796-54-1 (Pro-Opiomelanocortin)
RN  - EC 2.3.1.48 (Nuclear Receptor Coactivator 1)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Estrogen Receptor alpha/agonists/metabolism
MH  - Estrogens/*pharmacology
MH  - Female
MH  - Hypothalamus/drug effects/metabolism
MH  - Mice
MH  - Nuclear Receptor Coactivator 1/genetics/*metabolism
MH  - Phenols
MH  - Pro-Opiomelanocortin/metabolism
MH  - Protein Binding/drug effects
MH  - Pyrazoles/pharmacology
MH  - Steroidogenic Factor 1/genetics/*metabolism
PMC - PMC3529365
EDAT- 2012/12/06 06:00
MHDA- 2013/02/23 06:00
PMCR- 2014/01/01
CRDT- 2012/12/06 06:00
PHST- 2012/12/06 06:00 [entrez]
PHST- 2012/12/06 06:00 [pubmed]
PHST- 2013/02/23 06:00 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - en.2012-2007 [pii]
AID - EN-12-2007 [pii]
AID - 10.1210/en.2012-2007 [doi]
PST - ppublish
SO  - Endocrinology. 2013 Jan;154(1):150-8. doi: 10.1210/en.2012-2007. Epub 2012 Dec 4.