PMID- 23211991
OWN - NLM
STAT- MEDLINE
DCOM- 20140615
LR  - 20131021
IS  - 1873-3514 (Electronic)
IS  - 0028-3932 (Linking)
VI  - 51
IP  - 12
DP  - 2013 Oct
TI  - Decreased medial temporal lobe activation in BDNF (66)Met allele carriers during 
      memory encoding.
PG  - 2462-8
LID - S0028-3932(12)00505-2 [pii]
LID - 10.1016/j.neuropsychologia.2012.11.028 [doi]
AB  - The Met allele of the Brain-derived neurotrophic factor (BDNF) Val(66)Met 
      polymorphism has been associated with impaired activity-dependent secretion of 
      BDNF protein and decreased memory performance. Results from imaging studies 
      relating Val(66)Met to brain activation during memory processing have been 
      inconsistent, with reports of both increased and decreased activation in the 
      Medial Temporal Lobe (MTL) in Met carriers relative to Val homozygotes. Here, we 
      extensively studied BDNF Val(66)Met in relation to brain activation and white 
      matter integrity as well as memory performance in a large imaging (n=194) and 
      behavioral (n=2229) sample, respectively. Functional magnetic resonance imaging 
      (fMRI) was used to investigate MTL activation in healthy participants in the age 
      of 55-75 years during a face-name episodic encoding and retrieval task. White 
      matter integrity was measured using diffusion tensor imaging. BDNF Met allele 
      carriers had significantly decreased activation in the MTL during encoding 
      processes, but not during retrieval processes. In contrast to previous proposals, 
      the effect was not modulated by age and the polymorphism was not related to white 
      matter integrity. Met carriers had lower memory performance than Val homozygotes, 
      but differences were subtle and not significant. In conclusion, the BDNF Met 
      allele has a negative influence on MTL functioning, preferentially during 
      encoding processes, which might translate into impaired episodic memory function.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Kauppi, Karolina
AU  - Kauppi K
AD  - Department of Integrative Medical Biology (Physiology) Umea University, SE-90187, 
      Umea, Sweden and Umea Center for Functional Brain Imaging (UFBI), Umea, Sweden. 
      Electronic address: karolina.kauppi@physiol.umu.se.
FAU - Nilsson, Lars-Goran
AU  - Nilsson LG
FAU - Adolfsson, Rolf
AU  - Adolfsson R
FAU - Lundquist, Anders
AU  - Lundquist A
FAU - Eriksson, Elias
AU  - Eriksson E
FAU - Nyberg, Lars
AU  - Nyberg L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121202
PL  - England
TA  - Neuropsychologia
JT  - Neuropsychologia
JID - 0020713
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Axons
MH  - Brain Mapping
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Memory, Episodic
MH  - Methionine/*genetics
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Temporal Lobe/*physiology
OTO - NOTNLM
OT  - Genetics
OT  - Imaging
OT  - Memory
OT  - Parahippocampus
OT  - Val(66)Met
EDAT- 2012/12/06 06:00
MHDA- 2014/06/16 06:00
CRDT- 2012/12/06 06:00
PHST- 2012/07/23 00:00 [received]
PHST- 2012/11/12 00:00 [revised]
PHST- 2012/11/17 00:00 [accepted]
PHST- 2012/12/06 06:00 [entrez]
PHST- 2012/12/06 06:00 [pubmed]
PHST- 2014/06/16 06:00 [medline]
AID - S0028-3932(12)00505-2 [pii]
AID - 10.1016/j.neuropsychologia.2012.11.028 [doi]
PST - ppublish
SO  - Neuropsychologia. 2013 Oct;51(12):2462-8. doi: 
      10.1016/j.neuropsychologia.2012.11.028. Epub 2012 Dec 2.